Skip to main content

Table 1 Comparison of fractionated irradiation effect on CIC population, CICs markers and corresponding sphere forming capacity.

From: Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment

MCF-7
CD24Low/-/CD44Hight ZsGreen-cODC+
Dose % of CICs (+/- SEM) Sphere forming capacity Sphere forming capacity % of CICs (+/- SEM) Dose
0 3.01 (+/- 0.61),
P value
9.4 (+/- 0.5),
P value
12.32 (+/- 2.01),
P value
2.17 (+/- 0.47),
P value
0
2 6.54 (+/- 1.95),
P = 0.095
13.49 (+/- 1.32),
P = 0.01
15.25 (+/- 3.2),
P = 0.661
3.70 (+/- 0.52),
P = 0.051
3
2 × 2 8.04 (+/- 1.47),
P = 0.036
10.76 (+/- 0.96),
P = 0.137
17.54 (+/- 4.15),
P = 0.096
3.13 (+/- 0.53),
P = 0.252
2 × 3
4 × 2 8.56 (+/- 1.21),
P = 0.020
11.85 (+/- 1.81),
P = 0.198
17.93 (+/- 2.33),
P = 0.051
6.73 (+/- 1.33),
P = 0.141
3 × 3
6 × 2 9.10 (+/- 1.04),
P = 0.029
11.85 (+/- 1.48),
P = 0.035
24.52 (+/- 4.50),
P = 0.048
11.26 (+/- 2.06),
P = 0.091
4 × 3
8 × 2 4.78 (+/- 0.34)
P = 0.229
11.85 (+/- 1.27),
P = 0.002
25.37 (+/- 5.2),
P = 0.039
12.64 (+/- 1.91),
P = 0.044
5 × 3
T47D
CD24 Low/- /CD44Hight ZsGreen-cODC+
Dose % of CICs (+/- SEM) Sphere forming capacity Sphere forming capcity % of CICs (+/- SEM) Dose
0 0.35 (+/- 0.06),
P value
9.46 (+/- 2.20),
P value
3.35 (+/- 2.01),
P value
2.47 (+/- 0.88),
P value
0
2 0.34 (+/- 0.03),
P = 0.868
6.74 (+/- 1.31),
P = 0.014
3.13 (+/- 2.69),
P = 0.231
4.31 (+/- 1.13),
P = 0.029
3
2 × 2 0.43 (+/- 0.08),
P = 0.471
13.76 (+/- 4.01),
P = 0.146
6.48 (+/- 3.14),
P = 0.091
9.72 (+/- 2.81),
P = 0.068
2 × 3
4 × 2 2.04 (+/- 0.12),
P = 0.001
12.74 (+/- 4.58),
P = 0.157
9.96 (+/- 2.33),
P = 0.049
16.09 (+/- 5.57),
P = 0.103
3 × 3
6 × 2 0.68 (+/- 0.04),
P = 0.007
17.99 (+/- 5.17),
P = 0.027
12 (+/- 2.66),
P = 0.033
24.06 (+/- 4.15),
P = 0.025
4 × 3
8 × 2 0.29 (+/- 0.01),
P = 0.449
18.92 (+/- 5.83),
P = 0.018
7.65 (+/- 2.55),
P = 0.055
21.133 (+/- 1.87),
P = 0.015
5 × 3