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Table 1 Comparison of fractionated irradiation effect on CIC population, CICs markers and corresponding sphere forming capacity.

From: Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment

MCF-7
CD24Low/-/CD44Hight ZsGreen-cODC+
Dose % of CICs (+/- SEM) Sphere forming capacity Sphere forming capacity % of CICs (+/- SEM) Dose
0 3.01 (+/- 0.61), P value 9.4 (+/- 0.5), P value 12.32 (+/- 2.01), P value 2.17 (+/- 0.47), P value 0
2 6.54 (+/- 1.95), P = 0.095 13.49 (+/- 1.32), P = 0.01 15.25 (+/- 3.2), P = 0.661 3.70 (+/- 0.52), P = 0.051 3
2 × 2 8.04 (+/- 1.47), P = 0.036 10.76 (+/- 0.96), P = 0.137 17.54 (+/- 4.15), P = 0.096 3.13 (+/- 0.53), P = 0.252 2 × 3
4 × 2 8.56 (+/- 1.21), P = 0.020 11.85 (+/- 1.81), P = 0.198 17.93 (+/- 2.33), P = 0.051 6.73 (+/- 1.33), P = 0.141 3 × 3
6 × 2 9.10 (+/- 1.04), P = 0.029 11.85 (+/- 1.48), P = 0.035 24.52 (+/- 4.50), P = 0.048 11.26 (+/- 2.06), P = 0.091 4 × 3
8 × 2 4.78 (+/- 0.34) P = 0.229 11.85 (+/- 1.27), P = 0.002 25.37 (+/- 5.2), P = 0.039 12.64 (+/- 1.91), P = 0.044 5 × 3
T47D
CD24 Low/- /CD44Hight ZsGreen-cODC+
Dose % of CICs (+/- SEM) Sphere forming capacity Sphere forming capcity % of CICs (+/- SEM) Dose
0 0.35 (+/- 0.06), P value 9.46 (+/- 2.20), P value 3.35 (+/- 2.01), P value 2.47 (+/- 0.88), P value 0
2 0.34 (+/- 0.03), P = 0.868 6.74 (+/- 1.31), P = 0.014 3.13 (+/- 2.69), P = 0.231 4.31 (+/- 1.13), P = 0.029 3
2 × 2 0.43 (+/- 0.08), P = 0.471 13.76 (+/- 4.01), P = 0.146 6.48 (+/- 3.14), P = 0.091 9.72 (+/- 2.81), P = 0.068 2 × 3
4 × 2 2.04 (+/- 0.12), P = 0.001 12.74 (+/- 4.58), P = 0.157 9.96 (+/- 2.33), P = 0.049 16.09 (+/- 5.57), P = 0.103 3 × 3
6 × 2 0.68 (+/- 0.04), P = 0.007 17.99 (+/- 5.17), P = 0.027 12 (+/- 2.66), P = 0.033 24.06 (+/- 4.15), P = 0.025 4 × 3
8 × 2 0.29 (+/- 0.01), P = 0.449 18.92 (+/- 5.83), P = 0.018 7.65 (+/- 2.55), P = 0.055 21.133 (+/- 1.87), P = 0.015 5 × 3