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Table 4 Comparison of pathologic features of ER-positive BRCA1-associated breast cancers and ER-positive sporadic breast cancers

From: Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features

Covariates BRCA1+ Sporadic  
  n % N % Logistic likelihood ratio test P
All 47 100 138 100  
Mean age in years (range) 46 (29-72)   46 (29-72)   
Histologic type      
   Invasive ductal only 35 74 78 57 0.03
   All others 12 26 60 43  
   Mixed ductal/lobular 10 21 25 18  
   Lobular 1 2 12 9  
   Mixed ductal + special type 0 0 8* 6  
   Special type 1+ 2 15++ 11  
Histologic grade      
   3 18 38 34 25 0.10
   2 15 32 69 50 0.39
   1 13 28 35 25 0.69
   Unknown 1 2 0 0  
Mitoses/10 HPF      
   >10 9 19 9 7 0.03
   6-10 12 26 31 22 0.67
   0-5 25 53 98 71 0.03
   Unknown 1 2 0 0  
Margins      
   Invasive 43 91 134 97 0.12
   Pushing 3 6 2 1 0.09
   Unknown 1 2 2 1  
Lymphocytic infiltrate      
   Moderate/marked 2 4 17 12 0.08
   None/mild 44 94 121 88  
   Unknown 1 2 0 0  
Geographic necrosis/fibrotic focus      
   Yes 7 15 9 7 0.09
   No 38 81 129 93  
   Unknown 2 4 0 0  
  1. ER, estrogen receptor; HPF, high powered field.
  2. Percentages calculated by column
  3. * Mixed ductal plus: mucinous (n = 4), invasive micropapillary (n = 2), invasive papillary (n = 1), tubular (n = 1)
  4. + tubular (n = 1)
  5. ++ tubular (n = 6), mucinous (n = 5), invasive micropapillary (n = 2), invasive cribriform (n = 1), mixed invasive
  6. micropapillary/mucinous (n = 1)