Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features

Table 4 Comparison of pathologic features of ER-positive BRCA1-associated breast cancers and ER-positive sporadic breast cancers

Covariates	BRCA1+		Sporadic
	n	%	N	%	Logistic likelihood ratio test P
All	47	100	138	100
Mean age in years (range)	46 (29-72)		46 (29-72)
Histologic type
Invasive ductal only	35	74	78	57	0.03
All others	12	26	60	43
Mixed ductal/lobular	10	21	25	18
Lobular	1	2	12	9
Mixed ductal + special type	0	0	8*	6
Special type	1⁺	2	15⁺⁺	11
Histologic grade
3	18	38	34	25	0.10
2	15	32	69	50	0.39
1	13	28	35	25	0.69
Unknown	1	2	0	0
Mitoses/10 HPF
>10	9	19	9	7	0.03
6-10	12	26	31	22	0.67
0-5	25	53	98	71	0.03
Unknown	1	2	0	0
Margins
Invasive	43	91	134	97	0.12
Pushing	3	6	2	1	0.09
Unknown	1	2	2	1
Lymphocytic infiltrate
Moderate/marked	2	4	17	12	0.08
None/mild	44	94	121	88
Unknown	1	2	0	0
Geographic necrosis/fibrotic focus
Yes	7	15	9	7	0.09
No	38	81	129	93
Unknown	2	4	0	0

ER, estrogen receptor; HPF, high powered field.
Percentages calculated by column
* Mixed ductal plus: mucinous (n = 4), invasive micropapillary (n = 2), invasive papillary (n = 1), tubular (n = 1)
+ tubular (n = 1)
++ tubular (n = 6), mucinous (n = 5), invasive micropapillary (n = 2), invasive cribriform (n = 1), mixed invasive
micropapillary/mucinous (n = 1)

ISSN: 1465-542X