Skip to main content

Table 3 PR and HER2 status of BRCA1-associated breast cancers

From: Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features

 

ER- BRCA1cancers

ER+ BRCA1cancers

 

n = 68

n = 49

PR positive

0

40

   HER2 +*

0

3 (1 IHC, 2 FISH)

   HER2 negative**

0

34

   HER2 equivocal^

0

2

   HER2 unknown

0

1

PR weak positive^^

2

6

   HER2 +*

0

1 (IHC)

   HER2 -**

2

4

   HER2 unknown

0

1

PR negative

59

1

   HER2 +*

3 (IHC)

0

   HER2 -**

48

1

   HER2 equivocal^

1 (FISH)

0

   HER2 unknown

7

 

PR unknown

7

2

   HER2 -**

6

2

   HER2 unknown

1

0

  1. ER, estrogen receptor; FISH, fluorescence in situ hybridization; HER, human epidermal growth factor receptor; IHC, immunohistochemistry; PR, progesterone receptor; -, negative; +, positive.
  2. * HER2 positive: HER2:CEP17 ratio by FISH >2.2 or IHC 3+ (no FISH performed)
  3. ** HER2 negative: HER2:CEP17 ratio by FISH <1.8 or IHC <3+ (no FISH performed)
  4. ^HER2 equivocal: HER2:CEP17 ratio by FISH 1.8 to 2.2
  5. ^^ Weak PR positive: 1 to 10% cells show nuclear staining for PR
Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us