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Table 3 PR and HER2 status of BRCA1-associated breast cancers

From: Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features

  ER- BRCA1cancers ER+ BRCA1cancers
  n = 68 n = 49
PR positive 0 40
   HER2 +* 0 3 (1 IHC, 2 FISH)
   HER2 negative** 0 34
   HER2 equivocal^ 0 2
   HER2 unknown 0 1
PR weak positive^^ 2 6
   HER2 +* 0 1 (IHC)
   HER2 -** 2 4
   HER2 unknown 0 1
PR negative 59 1
   HER2 +* 3 (IHC) 0
   HER2 -** 48 1
   HER2 equivocal^ 1 (FISH) 0
   HER2 unknown 7  
PR unknown 7 2
   HER2 -** 6 2
   HER2 unknown 1 0
  1. ER, estrogen receptor; FISH, fluorescence in situ hybridization; HER, human epidermal growth factor receptor; IHC, immunohistochemistry; PR, progesterone receptor; -, negative; +, positive.
  2. * HER2 positive: HER2:CEP17 ratio by FISH >2.2 or IHC 3+ (no FISH performed)
  3. ** HER2 negative: HER2:CEP17 ratio by FISH <1.8 or IHC <3+ (no FISH performed)
  4. ^HER2 equivocal: HER2:CEP17 ratio by FISH 1.8 to 2.2
  5. ^^ Weak PR positive: 1 to 10% cells show nuclear staining for PR