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Table 2 Comparison of pathologic characteristics of ER-negative and ER-positive BRCA1-associated breast cancers

From: Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features

Covariates ER- ER+ Logistic likelihood ratio test P
  n % n %  
All 68   49   
Histologic type      
   Invasive ductal only * 67 99 37 76 <0.001
   Other 1 1 12 24  
   Mixed ductal/lobular 1   10   
   Tubular 0   1   
   Lobular 0   1   
Histologic grade      
   3 * 66 97 20 41 <0.001
   1-2 2 3 28 57  
   Unknown (combined with 1-2) 0 0 1 2  
Mitotic activity      
   >10 mitoses per 10 HPF * 64 94 11 22 <0.001
   0-10 mitoses per 10 HPF 4 6 37 76  
   Unknown 0 0 1 2  
Margins      
   Invasive * 22 32 44 90 <0.001
   Pushing 41 60 4 8  
   Unknown 5 7 1 2  
Lymphocytic infiltrate      
   Moderate/marked * 20 29 3 6 0.003
   None/mild 46 68 45 92  
   Unknown * 2 3 1 2  
Geographic necrosis/fibrotic focus      
   Yes * 50 74 8 16 <0.001
   No 15 22 39 80  
   Unknown * 3 4 2 4  
Age of breast cancer      
   Median (range) 39.5 (28-73)   45 (29-72)   
   <40 34 50 15 31 0.03
   40-49 27 40 20 41 0.91
   ≥ 50 7 10 14 29 0.01
  1. ER, estrogen receptor; HPF, high-powered field; -, negative; +, positive.
  2. Percentages calculated by column
  3. (*) indicates this level of the covariate was included in the single covariate model