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Table 1 Clinical characteristics of women with ER-negative and ER-positive BRCA1-associated breast cancers

From: Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features

Covariates

ER-

ER+

Logistic likelihood ratio test P

 

n

%

N

%

 

All

114

66

58

34

 

Menopausal status

     

   Pre *

98

71

41

29

0.02

   Post

15

47

17

53

 

   Unknown

1

100

0

0

 

Age of breast cancer

     

   Median (range)

40 (27-73)

 

46 (29-72)

  

   <40

54

77

16

23

0.01

   40-49

48

65

26

35

0.73

   ≥ 50

12

43

16

57

0.005

Prior HRT

     

   Yes *

11

58

8

42

0.42

   No

101

67

50

33

 

   Unknown

2

100

0

0

 

Ashkenazi Jewish

     

   Yes *

55

71

23

29

0.32

   No

58

64

33

36

 

   Unknown *

1

33

2

67

 

First live birth before breast cancer?

     

   Yes *

86

65

46

35

0.57

   No

28

72

11

28

 

   Unknown

0

0

1

100

 

Age of first live birth (if before breast cancer)

     

   Median (range)

27 (15-45)

 

27 (19-42)

  

   ≥ 27 *

47

67

23

33

0.44

   <27

39

63

23

37

 

   No or unknown live births before breast cancer *

28

70

12

30

 

Tobacco (pack years)

     

   0 *

64

66

33

34

0.33

   >0

31

74

11

26

 

   Unknown *

19

58

14

42

 

Alcohol

     

   0-1 drinks/week *

65

68

30

32

0.75

   >1 drinks/week

45

64

25

36

 

   Unknown *

4

57

3

43

 
  1. ER, estrogen receptor; HRT, hormone replacement therapy; -, negative; +, positive.
  2. Percentages calculated by row
  3. (*) indicates this level of the covariate was included in the single covariate model.