Skip to main content

Table 1 Clinical characteristics of women with ER-negative and ER-positive BRCA1-associated breast cancers

From: Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features

Covariates ER- ER+ Logistic likelihood ratio test P
  n % N %  
All 114 66 58 34  
Menopausal status      
   Pre * 98 71 41 29 0.02
   Post 15 47 17 53  
   Unknown 1 100 0 0  
Age of breast cancer      
   Median (range) 40 (27-73)   46 (29-72)   
   <40 54 77 16 23 0.01
   40-49 48 65 26 35 0.73
   ≥ 50 12 43 16 57 0.005
Prior HRT      
   Yes * 11 58 8 42 0.42
   No 101 67 50 33  
   Unknown 2 100 0 0  
Ashkenazi Jewish      
   Yes * 55 71 23 29 0.32
   No 58 64 33 36  
   Unknown * 1 33 2 67  
First live birth before breast cancer?      
   Yes * 86 65 46 35 0.57
   No 28 72 11 28  
   Unknown 0 0 1 100  
Age of first live birth (if before breast cancer)      
   Median (range) 27 (15-45)   27 (19-42)   
   ≥ 27 * 47 67 23 33 0.44
   <27 39 63 23 37  
   No or unknown live births before breast cancer * 28 70 12 30  
Tobacco (pack years)      
   0 * 64 66 33 34 0.33
   >0 31 74 11 26  
   Unknown * 19 58 14 42  
Alcohol      
   0-1 drinks/week * 65 68 30 32 0.75
   >1 drinks/week 45 64 25 36  
   Unknown * 4 57 3 43  
  1. ER, estrogen receptor; HRT, hormone replacement therapy; -, negative; +, positive.
  2. Percentages calculated by row
  3. (*) indicates this level of the covariate was included in the single covariate model.