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Table 3 Age-specific familial relative risk for breast cancer by ER status of the index case tumour

From: Familial relative risks for breast cancer by pathological subtype: a population-based cohort study

Age of relative (years) † ER-negative ER-positive All cases
  OBS EXP FRR 95%CI OBS EXP FRR 95%CI OBS EXP FRR 95%CI
Index case <50*             
   <50† 26 7.65 3.40 2.04-4.75 60 22.21 2.70 2.01-3.39 129 50.62 2.55 2.09-3.01
   50 to 84 21 14.77 1.42 0.81-2.03 84 50.3 1.67 1.32-2.02 186 113.76 1.64 1.33-1.95
   0 to 84 47 22.43 2.10 1.48-2.71 144 72.51 1.99 1.65-2.32 315 164.37 1.92 1.70-2.13
Index case >= 50             
   <50 22 8.59 2.56 1.31-3.81 75 43.57 1.72 1.33-2.11 160 82.16 1.95 1.63-2.56
   50 to 84 52 37.04 1.40 1.01-1.80 339 190.09 1.78 1.59-1.98 604 359.53 1.68 1.54-1.82
   0 to 84 74 45.63 1.62 1.22-2.02 414 233.66 1.77 1.59-1.95 764 441.69 1.73 1.60-1.86
Index case any age             
   <50 48 16.24 2.96 2.04-3.87 135 65.78 2.05 1.70-2.40 289 132.78 2.18 1.92-2.44
   50 to 84 73 51.82 1.41 1.08-1.74 423 240.39 1.76 1.59-1.93 790 473.28 1.67 1.54-1.80
   0 to 84 121 68.06 1.78 1.44-2.11 558 306.17 1.82 1.67-1.98 1079 606.06 1.78 1.68-1.89
  1. CI: Confidence Interval; ER; estrogen receptor; EXP: expected; FRR: familial relative risk; OBS: observed.
  2. * age at which index is affected
  3. † age of relative (years) <50: relatives were followed up from birth up until censoring or age 50, whichever occurred first, 50 to 84: from age 50 to censoring, 0 to 85: from birth to censoring