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Table 1 Index case tumour subtypes and distribution of cases according to reported family history

From: Familial relative risks for breast cancer by pathological subtype: a population-based cohort study

Phenotype of index case tumour Number of tumours (%)** Number with affected relative (%) Number without affected relative (%) Comparison group for case-only analysis OR§ 95%CI P-valuee
ER-positive 3659 (81) 599 (82) 3060 (81) ER-negative 1.04 0.85-1.28 0.70
PR-positive 1709 (69) 267 (69) 1442 (69) PR-negative 1.01 0.79-1.27 0.96
HER2-positive 228 (12) 38 (13) 190 (12) HER2-negative 1.15 0.79-1.68 0.78
ER+PR+ 1581 (65) 247 (64) 1334 (65) ER-PR- 1.00 0.75-1.31 0.95
ER-PR+ 110 (4.5) 18 (5) 92 (5)     
ER+PR- 261 (11) 43 (11) 218 (11)     
ER or PR+ (luminal) 3787 (83) 619 (84) 3168 (83)     
ER or PR+ HER2+ (luminal HER2+) 138 (7) 23 (8) 115 (7) luminal HER2- 1.17 0.73-1.88 0.51
ER or PR+ HER2- (luminal HER2-) 1404 (75) 209 (74) 1195 (75)     
ER-PR-HER2+ (non-luminal HER2+) 76 (5) 11 (4) 65 (5) TN 1.02 0.48-2.16 0.96
ER-PR-HER2- (TN) 218 (13) 30 (12) 188 (13)     
  1. ER: estrogen receptor; HER2: human epidermal growth factor receptor; PR: progesterone receptor; TN: triple negative.
  2. * reported diagnosis of breast cancer in a first degree relative
  3. ** Number of tumours in phenotypic group as a percentage of those tested for that phenotype
  4. † Number of tumours in phenotypic group with an affected first degree relative as a percentage of cancers with measured phenotype and an affected first degree relative
  5. ‡ Number of tumours in phenotypic group without any affected first degree relative as a percentage of cancers with measured phenotype and without any affected relative
  6. §OR, 95% CI (confidence intervals) and P-values associated with family history of breast cancer in any first degree relative, adjusting for age at diagnosis of the index case.