EGCG sensitizes 4T1 tumors to taxol in Balb/c mice. (a) 4T1 cells were injected into Balb/c mice as described in Materials and Methods. When tumors became palpable, the mice were randomly assigned into different groups (n = 8 for control; n = 8 for EGCG group; n = 8 for taxol group; n = 10 for combination treatment), and treated with EGCG (30 mg/kg), taxol (10 mg/kg), or both. Tumor growth was monitored for 24 days. Asterisk = P < 0.05, significantly different from control, EGCG, or taxol group (two-way ANOVA, post-hoc test). Data are mean ± SE. (b) Tumors were dissected 24 days after inoculation of tumor cells into the mice. The tumor weight was measured. The combined data of tumor weight from two experiments was plotted (n = 15 for control; n = 15 for EGCG group; n = 15 for taxol group; n = 16 for combination treatment). Columns = mean of tumor weight; bars = SE. Asterisk = P < 0.05, significantly different from control or single agent.