Table 5 Functional enrichment of genes expressed lower in blood of breast cancer patients compared to healthy subjects
From: Gene expression profiling of peripheral blood cells for early detection of breast cancer
Biological process | Count | % | P-Value | Genes | Fold Enrichment | FDR |
|---|---|---|---|---|---|---|
GO:0044255 Cellular lipid metabolic process | 20 | 7.69% | 0.0008 | C10orf33, MBTPS1, PMVK, OSBPL7, SULT1A2, PEMT, LASS6, CMAS, SYK, PLAA, SULT1A4, INSIG1, IDI1, FDPS, HEXA, PECI, CYP2J2, ACAA1, SULT1A1, GRN, | 2.3 | 1.6 |
GO:0008202 Steroid metabolic process | 9 | 3.46% | 0.0022 | INSIG1, IDI1, MBTPS1, FDPS, PMVK, OSBPL7, SULT1A2, SULT1A1, SULT1A4, | 3.8 | 4.0 |
GO:0006629 Lipid metabolic process | 21 | 8.08% | 0.0027 | C10orf33, MBTPS1, ACAT2, PMVK, OSBPL7, SULT1A2, PEMT, LASS6, CMAS, SYK, PLAA, SULT1A4, INSIG1, IDI1, FDPS, HEXA, PECI, CYP2J2, ACAA1, SULT1A1, GRN, | 2.1 | 4.9 |
GO:0006584 Catecholamine metabolic process | 4 | 1.54% | 0.0057 | SULT1A2, HDC, SULT1A1, SULT1A4, | 10.3 | 10.1 |
GO:0018958 Phenol metabolic process | 4 | 1.54% | 0.0057 | SULT1A2, HDC, SULT1A1, SULT1A4, | 10.3 | 10.1 |