Table 4 Functional enrichment of genes expressed higher in blood of breast cancer patients compared to healthy subjects
From: Gene expression profiling of peripheral blood cells for early detection of breast cancer
Biological process | Count | % | P-value | Genes | Fold enrichment | FDR |
|---|---|---|---|---|---|---|
GO:0006412 Translation | 20 | 8.55% | 0.0037 | RPL26L1, LOC440587, RPS29, RPL37A, RPL11, UBA52, RPS3A, EEF1G, TRSPAP1, RPL36A, RPL24, RPL17, RPL14, RPL15, RPL4, RPL6, RPS25, ETF1, AARSD1, RPL12, | 2.0 | 6.6 |
GO:0042742 Defense response to bacterium | 5 | 2.14% | 0.0064 | DEFA3, LTF, CAMP, PPBP, S100A12, | 6.5 | 11.3 |
GO:0044249 Cellular biosynthetic process | 27 | 11.54% | 0.0112 | LOC440587, RPL26L1, ATP5E, UBA52, RPL11, RPL14, RPL4, ATP6V0B, RPS25, RPS29, RPL37A, RPS3A, ATP5L, EEF1G, TRSPAP1, RPL24, RNPEPL1, RPL36A, RPL17, GUK1, RPL15, PRODH, MTHFS, RPL6, ETF1, AARSD1, RPL12, | 1.6 | 18.9 |
GO:0009605 Response to external stimulus | 16 | 6.84% | 0.0115 | DEFA3, TIRAP, S100A12, CDKN2D, NMI, CXCR3, STAT3, RALBP1, CLU, PF4, AIF1, PPBP, C8B, CMTM5, ANXA1, GP1BB, | 2.0 | 19.4 |