Table 3 Age-adjusted incidence rate (AAIR) of invasive and in situ breast cancer according to hormone therapy (HT) use at baseline in 1995-1996 among menopausal women in the California Teachers Study
Period | Never HT | Past HT | Current E | Current EP |
|---|---|---|---|---|
| Â | AAIR (95% CI) | AAIR (95% CI) | AAIR (95% CI) | AAIR (95% CI) |
| Â | Invasive breast cancer | Â | ||
1996-99 | 399.0 (341.7-456.3) | 343.7 (268.8-418.6) | 567.5 (501.1-633.9) | 680.8 (576.7-784.8) |
2000-02 | 334.7 (278.5-390.9) | 410.6 (300.7-520.6) | 509.6 (438.9-580.2) | 782.7 (687.1-878.2) |
2003-05 | 374.1 (308.1-440.1) | 297.8 (218.5-377.2) | 376.4 (314.7-438.1) | 424.6 (353.5-495.7) |
% change 1996-99 to 2000-02 | -16.1% P = 0.13 | 19.5% P = 0.31 | -10.2% P = 0.11 | 15.0% P = 0.016 |
% change 2000-02 to 2003-05 | 11.8% P = 0.38 | -27.5% P = 0.17 | -26.1% P = 0.010 | -45.8% P < 0.001 |
| Â | In Situ breast cancer | Â | ||
1996-99 | 65.0 (41.1-88.9) | 87.5 (43.2-131.7) | 85.4 (60.2-110.6) | 187.0 (128.3-245.6) |
2000-02 | 64.5 (39.5-89.6) | 96.6 (29.7-163.5) | 107.5 (78.1-136.9) | 169.2 (128.6-209.9) |
2003-05 | 103.1 (60.5-145.7) | 131.7 (163.5-160.6) | 82.4 (56.5-108.3) | 90.1 (65.4-114.8) |
% change 1996-99 to 2000-02 | -0.8% P = 0.98 | 10.4% P = 0.82 | 25.9% P = 0.12 | -9.5% P = 0.38 |
% change 2000-02 to 2003-05 | 59.8% P = 0.10 | 36.3% P = 0.51 | -23.3% P = 0.23 | -46.7% P = 0.008 |