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Table 2 Germ-line variants and clinicopathologic characteristics of breast cancer patients by study

From: Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients

  

ABCS

N = 1076

HABCS

N = 152

HEBCS

N = 599

SEARCH

N = 1922

P value*

  

N

%

N

%

N

%

N

%

 

MDM2 SNP309

TT

444

41.3

55

36.2

183

30.6

774

40.3

 
 

GT

487

45.3

73

48.0

311

51.9

913

47.5

 
 

GG

145

13.5

24

15.8

105

17.5

235

12.2

< 0.001

TP53 R72P

GG

570

53.0

85

55.9

314

52.4

1052

54.7

 
 

GC

422

39.2

55

36.2

236

39.4

733

38.1

 
 

CC

84

7.8

12

7.9

49

8.2

137

7.1

0.9

Stage

1

341

31.9

83

69.2

205

36.9

861

52.4

 
 

2

581

54.4

36

30.0

295

53.1

713

43.4

 
 

3

146

13.7

1

0.8

56

10.1

69

4.2

< 0.001

 

Missing

8

 

32

 

43

 

279

  

Differentiation grade

1

338

35.8

9

8.7

138

24.6

368

25.4

 
 

2

317

33.6

55

53.4

243

43.2

647

44.7

 
 

3

288

30.5

39

37.9

181

32.2

431

29.8

< 0.001

 

Missing

133

 

49

 

37

 

476

  

ER status tumor

Negative

240

34.2

18

15.4

135

23.2

175

19.8

 
 

Positive

461

65.8

99

84.6

446

76.8

708

80.2

< 0.001

 

Missing

375

 

35

 

18

 

1039

  

p53 status tumor

Negative

473

70.4

  

335

76.7

   
 

Positive

199

29.6

  

102

23.3

  

0.02

 

Missing

404

 

152

 

162

 

1922

  

Vital status patient

Alive

694

64.5

129

84.9

462

77.1

1596

83.0

 
 

Deceased, all

382

35.5

23

15.1

137

22.9

326

17.0

< 0.001

 

Deceased, breast cancer

337

 

20

 

105

    

Years of diagnosis

Range

1974 to 1994

 

1997 to 2003

 

1997 to 1998

 

1991 to 1996

  

Age at diagnosis

Mean ± SD

42.8

5.2

56.8

11.3

56.4

12.8

50.1

7.7

< 0.001

Follow-up

Mean ± SD

10.5

5.7

6.5

1.9

7.3

2.1

6.3

2.1

< 0.001

  1. * P value of comparison of either categories of non-missing data among studies (by chi-square) or comparison of continuous data (by t-test).