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Figure 2 | Breast Cancer Research

Figure 2

From: Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients

Figure 2

Cumulative overall survival of breast cancer patients by MDM2 SNP309 and TP53 R72P genotypes. Each figure shows Kaplan Meier survival curves of MDM2 SNP309 genotypes within one group of TP53 R72P genotype. (a) TP53 GG genotype (ns); (b) TP53 GC genotype (P = 0.006); (c) TP53 CC genotype (ns). The numbers at start of follow-up were: Figure A: TT n = 798, TG n = 939, GG n = 281; B: TT n = 545, TG n = 698, GG n = 200; C: TT n = 110, TG n = 144, GG n = 25. Within the TP53 C-allele carriers (Figure A and B combined), MDM2 GG carriers had significantly worse survival compared to TT/TG carriers combined: 64% versus 75%, P = 0.001.

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Breast Cancer Research

ISSN: 1465-542X

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