Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast

Breast Cancer Research

Table 3 Comparison of differential allelic expression between breast and blood (fresh and transformed)

Gene	SNP	Informative Heterozygotes			Wilcoxon rank sum test p- value
		Blood	LCL	Breast	Blood vs LCL	Blood vs Breast	LCL vs Breast
BRCA1	rs799917	27	13	6	4.40E-06	0.011	0.016
BRCA2	rs144848	37	6	8	NA	0.744	NA
C1qA	rs172378	16	5	7	0.076	NA	NA
CCND3	rs1051130	17	12	7	0.207	0.266	0.090
EMSY	rs228611	37	7	13	2.26E-05	0.029	0.047
GPX1	rs1050450	14	4	12	NA	NA	NA
GPX4	rs713041	21	8	5	0.366	0.057	0.091
MLH3	rs175080	35	12	13	NA	NA	0.772
MTHFR	rs1801133	33	7	12	0.030	1.53E-04	0.703
NBS1	rs709816	21	9	13	0.003	0.001	0.947
TP53	rs1042522	16	8	16	0.192	1.34E-05	3.80E-04
TRXR2	rs1139793	29	9	14	0.069	0.826	0.007

Wilcox rank sum tests were performed to compare deviations of differential allelic expression variance (only genes showing DAE were introduced in the analysis). Blood corresponds to fresh B cell samples and LCL to EBV transformed lymphoblastoid cell lines. DAE = differential allelic expression; LCL, EBV transformed lymphoblastoid cell lines.

ISSN: 1465-542X