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Table 1 DNA amplification rates at the region 13q34 in different analyses performed by our group

From: Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes

  

DNA amplification rate % (n)

Chromosomal region

Analysis

BRCA1

BRCA2

Non-BRCA1/2

Sporadic

Total

13q31-q34

cCGH*

11.6 (3/26)

5.6 (1/18)

0 (0/36)

-

5.0 (4/80)

13q34

aCGH**

15.8 (3/19)

4.2 (1/24)

0 (0/31)

10.5 (2/19)

6.5 (6/93)

13q34

FISH+

9.5 (2/21)

0 (0/14)

4.8 (3/66)

4.2 (8/192)

4.4 (13/293)

Total

 

8.1 (3/37)

2.6 (1/38)

3.3 (3/92)

4.7 (10/211)

4.5 (17/378)

  1. The percentage of cases with Amp13q34 is shown.
  2. *Melchor et al., 2005 [21]. Genomic amplification is considered when CGH ratio > 1.5 (see Figure 1a).
  3. **Melchor et al., 2007 [28]. Amplification is regarded as genomic segments with log2ratio ≥ 0.4.
  4. +Current study. Numbers correspond to cases in the tissue microarrays that were analyzable. We considered amplification when in tumor areas > 50% tumor cells showed > 3 times as many 13q34 signals as 13q12.11 copy signals.
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Breast Cancer Research

ISSN: 1465-542X

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