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Table 2 Relative risks of local recurrence and of any second breast cancer at five years associated with diagnosis year

From: Declining recurrence among ductal carcinoma in situ patients treated with breast-conserving surgery in the community setting

 

Local recurrence

Any second breast cancer

 

RRa

95% CIb

RRa

95% CIb

Univariate models

Diagnosis year

    

   1990-1991

1.0

(reference)

1.0

(reference)

   1992-1993

0.7

0.5-1.0

0.8

0.6-1.1

   1994-1995

0.8

0.6-1.2

0.9

0.6-1.2

   1996-1997

0.7

0.5-1.0

0.7

0.5-0.9

   1998-1999

0.4

0.3-0.6

0.4

0.3-0.6

 

P for trend < 0.0001

P for trend < 0.0001

Adjuvant therapy

    

   None (BCSc only)

1.0

(reference)

1.0

(reference)

   Radiotherapy

0.4

0.3-0.5

0.6

0.5-0.7

   Tamoxifen

0.1

0.04-0.6

0.2

0.1-0.6

   Radiotherapy+Tamoxifen

0.1

0.05-0.4

0.3

0.1-0.5

Multivariable model (with treatment variables)

Diagnosis year d

    

   1990-1991

1.0

(reference)

1.0

(reference)

   1992-1993

0.8

0.6-1.2

0.9

0.7-1.3

   1994-1995

1.0

0.7-1.4

1.0

0.7-1.3

   1996-1997

0.8

0.6-1.2

0.8

0.6-1.1

   1998-1999

0.6

0.4-0.8

0.6

0.4-0.8

 

P for trend = 0.008

P for trend = 0.0002

Adjuvant therapy

    

   None (BCSc only)

1.0

(reference)

1.0

(reference)

   Radiotherapy

0.4

0.3-0.6

0.6

0.5-0.8

   Tamoxifen

0.2

0.04-0.7

0.2

0.1-0.7

   Radiotherapy+Tamoxifen

0.2

0.06-0.4

0.3

0.2-0.6

  1. a Relative Risk
  2. b Confidence Interval
  3. c Breast-conserving surgery
  4. d Model adjusted for adjuvant therapy (none, radiotherapy, tamoxifen)