Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival

Pai, Vaibhav P; Marshall, Aaron M; Hernandez, Laura L; Buckley, Arthur R; Horseman, Nelson D

doi:10.1186/bcr2448

Breast Cancer Research

Table 1 Modification of 5-HT receptor expression with human breast cancer status - Oncomine study

From: Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival

Study Type	Receptor Type	Variable	Direction of Change	P-value (T-test)	Oncomine data source
Tumor grade/stage	HTR2B	Normal vs Breast Carcinoma	Higher in Cancer	0.002	Richardson et. al. [77]
		Tumor stage N0-N3	Increase with stage	0.006	Bittner et. al. [78]
	HTR2C	Tumor stage N0-N3	Increase with stage	0.009	Yu et. al. [79]
	HTR7	Grade I to III	Increase with grade	<0.0001	Ivshina et. al. [80]
				0.0001	Miller et. al. [81]
				<0.01	Ginestier C et. al. [82]
More aggressive vs Less aggressive breast cancers	HTR1F	5 yrs recurrence- vs 5 yrs recurrence+	Higher in recurring tumors	0.005	VantVeer et. al. [83]
	HTR2B	Lymph node- vs Lymph node+	Higher in lymph node +	0.006	Chin et. al. [84]
	HTR2C	Primary vs Metastatic tumors	Higher in metastatic	0.001	Bittner et. al. [78]
		Her2/neu- vs Her2/neu+	Higher in Her2/neu+	0.00057	Minn et. al. [85]
				0.002	Hess KR et. al. [86]
	HTR5A	P53-mutant vs p53-WT	Higher in p53-mutant	<0.0001	Miller et. al. [81]
	HTR7	P53-mutant vs p53-WT	Higher in p53-mutant	0.008	Miller et. al. [81]
Steroid receptor status	HTR1F	ER+ vs ER-	Higher in ER+	0.0001	Sotiriou et. al. [87]
	HTR2B	ER+ vs ER-	Higher in ER+	0.00014	Wang et. al. [88]
				0.0004	Sotitiou et. al. [87]
				0.00014	Desmedt et. al. [89]
		Luminal vs Basal Tumors	Lower in Basal (ER-)	<0.0001	Farmer et. al. [90]
	HTR4	ER+ vs ER-	Higher in ER+	0.001	Chi et. al. [84]
	HTR7	ER+ vs ER-	Higher in ER+	<0.0001	VanderVijer et. al. [91]
				0.00087	Bittner et. al. [78]
Human Mammary Cell lines	HTR2B	HMEC-Normal (GFP) vs c-Myc transformation	Higher in c-Myc transformed cells	0.001	Bild AH et. al. [92]
	HTR7	HMEC-Normal (GFP) vs activated H-Ras	Higher in H-Ras cells	0.00028	Bild AH et. al. [92]

Receptor mRNAs encoding 5-HT_1F (HTR1F), 5-HT_2B (HTR2B), 5-HT_2C (HTR2C), 5-HT₄ (HTR4), 5-HT_5A (HTR5A) and 5-HT₇ (HTR7) sorted as per tumor stage/grade, ER status, tumor aggressiveness and human mammary cell line transformation. Abbreviations: (ER+) - Estrogen Receptor Positive, (ER-) - Estrogen Receptor Negative. (HMEC) - human mammary epithelial cells.

Back to article page

ISSN: 1465-542X

Contact us

Submission enquiries: journalsubmissions@springernature.com