Figure 2
From: Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival
Changes in TPH1 signal in human breast tumors. (A) Representative image of normal human breast tissue (BT) from the tissue microarray stained for TPH1 (brown) and counterstained with hematoxylin. A corresponding no primary antibody control section is depicted on the bottom left. Magnified image shows details of epithelial staining and occasional positive cells in stroma. (B-D) Results depicting quantification of TPH1 immunostaining from blindly scored tissue microarray sections. The section scores for TPH1 were sorted as per human cancer cell line core (B), estrogen receptor (ER) status (C) and progesterone receptor (PR) status (D). TPH1 staining was reduced in ER negative tumors, but unaffected by PR status. Error bars represent ± SEM. *P < 0.05 in comparison with normal BT for (A).