Skip to main content

Table 5 Breast cancer risk according to MRI absolute dense volume and Cumulus and visual assessment absolute dense areas (Medial-Lateral Oblique view)

From: Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study

  No. women No. cancers No. pyears IRR - binary
(95% CI) P-value
IRR - trend
(95% CI) P-value
Adjusted for age ≥ 45 years
MRI dense volume 651 56 4,291 2.08 (1.20, 3.62) 0.009 1.33 (1.05, 1.70) 0.020
Cumulus MLO dense area 607 42 4,109 0.76 (0.41, 1.41) 0.39 0.96 (0.73, 1.25) 0.75
Adjusted for age ≥ 45 years, BMI and parity
MRI dense volume 499 40 3,345 1.87 (0.98, 3.56) 0.058 1.25 (0.94, 1.66) 0.13
Cumulus MLO dense area 456 30 3,123 0.64 (0.30, 1.36) 0.25 0.84 (0.60, 1.19) 0.33
Adjusted for age ≥ 45 years and BRCA1/2 status/carrier probability
MRI dense volume 615 53 4,046 2.31 (1.31, 4.07) 0.004 1.42 (1.11, 1.83) 0.006
Cumulus MLO dense area 591 39 4,006 1.19 (0.63, 2.26) 0.59 1.11 (0.82, 1.50) 0.52
Adjusted for age ≥ 45 years, BRCA1/2 status/carrier probability, BMI and parity
MRI dense volume 485 39 3,240 2.16 (1.12, 4.17) 0.021 1.35 (1.01, 1.80) 0.042
Cumulus MLO dense area 450 29 3,078 0.99 (0.46, 2.13) 0.99 0.95 (0.64, 1.41) 0.81
  1. BRCA1/2 carrier probabilities estimated using Boadicea for untested women and those with an uninformative test result.
  2. Pyears = number of person-years in study and follow-up period
  3. IRR - trend = incidence rate ratio, estimated assuming a linear trend in risk ratio between quartiles
  4. IRR - binary = incidence rate ratio for the higher two quartiles versus the lower two quartiles
  5. CI = confidence interval.