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Table 3 Breast cancer risk according to MRI percent dense volume, Cumulus and VA percent dense area (Medial-Lateral Oblique view)

From: Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study

 

No. women

No. cancers

No. pyears

IRR - binary (95% CI) P-value

IRR - trend (95% CI) P-value

Adjusted for age ≥ 45 years

MRI % dense volume

655

56

4,328

1.68 (0.97, 2.94) 0.066

1.17 (0.92, 1.49) 0.21

Cumulus MLO % dense area

607

42

4,109

1.12 (0.61, 2.05) 0.72

1.06 (0.81, 1.40) 0.66

VA MLO % dense area

599

42

4,060

1.61 (0.87, 2.98) 0.13

1.25 (0.96, 1.64) 0.098

Adjusted for age ≥ 45 years, tamoxifen use, BMI and parity

MRI % dense volume

503

40

3,381

1.32 (0.64, 2.73) 0.46

1.10 (0.79, 1.54) 0.56

Cumulus MLO % dense area

456

30

3,123

0.89 (0.39, 2.03) 0.78

0.92 (0.63, 1.35) 0.68

VA MLO % dense area

450

30

3,085

1.61 (0.71, 3.68) 0.26

1.22 (0.84, 1.76) 0.29

Adjusted for age ≥ 45 years and BRCA1/2 status/carrier probability

MRI % dense volume

619

53

4,083

2.04 (1.16, 3.59) 0.013

1.30 (1.01, 1.67) 0.039

Cumulus MLO % dense area

591

39

4,006

1.82 (0.96, 3.45) 0.065

1.26 (0.95, 1.68) 0.11

VA MLO % dense area

583

39

3,957

2.24 (1.18, 4.26) 0.014

1.47 (1.11, 1.96) 0.008

Adjusted for age ≥ 45 years, BRCA1/2 status/carrier probability, BMI and parity

MRI % dense volume

489

39

3,276

1.76 (0.82, 3.77) 0.15

1.26 (0.87, 1.81) 0.22

Cumulus MLO % dense area

450

29

3,078

1.43 (0.62, 3.32) 0.41

1.09 (0.73, 1.63) 0.66

VA MLO % dense area

444

29

3,040

1.84 (0.81, 4.19) 0.15

1.37 (0.94, 2.02) 0.11

  1. BRCA1/2 carrier probabilities estimated using Boadicea for untested women and those with an uninformative test result.
  2. Pyears = number of person-years in study and follow-up period
  3. IRR - trend = incidence rate ratio, estimated assuming a linear trend in risk ratio between quartiles
  4. IRR - binary = incidence rate ratio for the higher two quartiles versus the lower two quartiles
  5. CI = confidence interval.