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Table 3 Breast cancer risk according to MRI percent dense volume, Cumulus and VA percent dense area (Medial-Lateral Oblique view)

From: Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study

  No. women No. cancers No. pyears IRR - binary (95% CI) P-value IRR - trend (95% CI) P-value
Adjusted for age ≥ 45 years
MRI % dense volume 655 56 4,328 1.68 (0.97, 2.94) 0.066 1.17 (0.92, 1.49) 0.21
Cumulus MLO % dense area 607 42 4,109 1.12 (0.61, 2.05) 0.72 1.06 (0.81, 1.40) 0.66
VA MLO % dense area 599 42 4,060 1.61 (0.87, 2.98) 0.13 1.25 (0.96, 1.64) 0.098
Adjusted for age ≥ 45 years, tamoxifen use, BMI and parity
MRI % dense volume 503 40 3,381 1.32 (0.64, 2.73) 0.46 1.10 (0.79, 1.54) 0.56
Cumulus MLO % dense area 456 30 3,123 0.89 (0.39, 2.03) 0.78 0.92 (0.63, 1.35) 0.68
VA MLO % dense area 450 30 3,085 1.61 (0.71, 3.68) 0.26 1.22 (0.84, 1.76) 0.29
Adjusted for age ≥ 45 years and BRCA1/2 status/carrier probability
MRI % dense volume 619 53 4,083 2.04 (1.16, 3.59) 0.013 1.30 (1.01, 1.67) 0.039
Cumulus MLO % dense area 591 39 4,006 1.82 (0.96, 3.45) 0.065 1.26 (0.95, 1.68) 0.11
VA MLO % dense area 583 39 3,957 2.24 (1.18, 4.26) 0.014 1.47 (1.11, 1.96) 0.008
Adjusted for age ≥ 45 years, BRCA1/2 status/carrier probability, BMI and parity
MRI % dense volume 489 39 3,276 1.76 (0.82, 3.77) 0.15 1.26 (0.87, 1.81) 0.22
Cumulus MLO % dense area 450 29 3,078 1.43 (0.62, 3.32) 0.41 1.09 (0.73, 1.63) 0.66
VA MLO % dense area 444 29 3,040 1.84 (0.81, 4.19) 0.15 1.37 (0.94, 2.02) 0.11
  1. BRCA1/2 carrier probabilities estimated using Boadicea for untested women and those with an uninformative test result.
  2. Pyears = number of person-years in study and follow-up period
  3. IRR - trend = incidence rate ratio, estimated assuming a linear trend in risk ratio between quartiles
  4. IRR - binary = incidence rate ratio for the higher two quartiles versus the lower two quartiles
  5. CI = confidence interval.