Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study

Table 2 Relationship between measures of breast density and six binary variables

	No. 'Yes'	No. 'No'	coefficient (95% CI)	P-value
MRI % dense volume (log)
Ever smoker	229	304	-0.01 (-0.12, 0.10)	0.82
Post-menopausal	108	418	-0.32 (-0.45, -0.19)	< 0.001
Ever pregnant	466	64	-0.22 (-0.39, -0.06)	0.008
Ever tamoxifen use	28	506	-0.44 (-0.67, -0.20)	< 0.001
Previous OC use	426	106	-0.16 (-0.29, -0.02)	0.023
Ever HRT use	17	97	0.01 (-0.32, 0.33)	0.98
Cumulus %dense area
Ever smoker	206	270	0.21 (-3.43, 3.86)	0.91
Post-menopausal	101	372	-8.95 (-13.3, -4.60)	< 0.001
Ever pregnant	424	49	-7.10 (-13.0, -1.18)	0.019
Ever tamoxifen use	30	447	-10.4 (-17.8, -3.07)	0.006
Previous OC use	379	96	0.35 (-4.15, 4.86)	0.88
Ever HRT use	12	73	1.11 (-11.2, 13.4)	0.86
Visually Assessed % dense area
Ever smoker	202	268	-1.25 (-5.05, 2.56)	0.52
Post-menopausal	101	366	-10.3 (-14.8, -5.75)	< 0.001
Ever pregnant	418	49	-8.16 (-14.3, -2.03)	0.009
Ever tamoxifen use	29	442	-13.0 (-20.8, -5.28)	0.001
Previous OC use	374	95	-0.39 (-5.08, 4.31)	0.87
Ever HRT use	11	71	5.34 (-7.16, 17.8)	0.41
MRI dense volume (×10 ³ , log)
Ever smoker	226	303	0.05 (-0.07, 0.16)	0.43
Post-menopausal	107	415	-0.05 (-0.19, 0.09)	0.50
Ever pregnant	463	63	-0.17 (-0.34, 0.00)	0.05
Ever tamoxifen use	28	502	-0.07 (-0.32, 0.18)	0.60
Previous OC use	423	106	-0.08 (-0.22, 0.06)	0.24
Ever HRT use	17	97	0.12 (-0.24, 0.47)	0.52
Cumulus dense area (×10 ³ )
Ever smoker	206	270	41.9 (-156, 240)	0.68
Post-menopausal	101	372	-251 (-491, -10.6)	0.041
Ever pregnant	424	49	-273 (-596, 49.7)	0.098
Ever tamoxifen use	30	447	-273 (-677, 131)	0.19
Previous OC use	379	96	56.1 (-189, 301)	0.65
Ever HRT use	12	73	180 (-419, 778)	0.56

ISSN: 1465-542X