Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study

Thompson, Deborah J; Leach, Martin O; Kwan-Lim, Gek; Gayther, Simon A; Ramus, Susan J; Warsi, Iqbal; Lennard, Fiona; Khazen, Michael; Bryant, Emilie; Reed, Sadie; Boggis, Caroline RM; Evans, D Gareth; Eeles, Rosalind A; Easton, Douglas F; Warren, Ruth ML

doi:10.1186/bcr2447

Table 1 Relationship between measures of breast density and eight continuous variables, by quartile

From: Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study

				Quartile 2	Quartile 3	Quartile 4
	N	P_trend	P_het	Coefficient (95% CI)	Coefficient (95% CI)	Coefficient (95% CI)
MRI % dense volume (log)
age	655	< 0.001	< 0.001	-0.02 (-0.14, 0.11)	-0.08 (-0.22, 0.06)	-0.38 (-0.52, -0.25)
weight	519	< 0.001	< 0.001	-0.29 (-0.42, -0.16)	-0.43 (-0.56, -0.29)	-0.83 (-0.97, -0.70)
BMI	517	< 0.001	< 0.001	-0.22 (-0.35, -0.09)	-0.48 (-0.61, -0.35)	-0.86 (-0.99, -0.72)
hip	429	< 0.001	< 0.001	-0.17 (-0.31, -0.03)	-0.29 (-0.45, -0.12)	-0.68 (-0.84, -0.53)
Waist	438	< 0.001	< 0.001	-0.10 (-0.25, 0.06)	-0.29 (-0.43, -0.14)	-0.65 (-0.81, -0.49)
Chest	449	< 0.001	< 0.001	-0.22 (-0.36, -0.09)	-0.37 (-0.52, -0.22)	-0.86 (-1.01, -0.70)
WHR	427	0.006	0.032	-0.09 (-0.26, 0.08)	-0.09 (-0.26, 0.08)	-0.26 (-0.43, -0.09)
Parity	633	0.008	0.052	-0.19 (-0.36, -0.01)	-0.19 (-0.33, -0.05)	-0.22 (-0.39, -0.05)
Cumulus % dense area
age	607	0.003	0.004	-1.58 (-5.87, 2.71)	-0.53 (-5.20, 4.14)	-7.66 (-12.2, -3.08)
weight	464	< 0.001	< 0.001	-9.21 (-13.7, -4.72)	-17.2 (-21.7, -12.7)	-26.6 (-31.0, -22.1)
BMI	462	< 0.001	< 0.001	-7.97 (-12.4, -3.56)	-15.7 (-20.1, -11.3)	-27.6 (-32.0, -23.3)
hip	378	< 0.001	< 0.001	-5.59 (-10.4, -0.78)	-10.7 (-16.3, -5.10)	-24.4 (-29.3, -19.6)
Waist	386	< 0.001	< 0.001	-3.56 (-8.99, 1.86)	-11.3 (-16.2, -6.47)	-20.9 (-26.0, -15.8)
Chest	397	< 0.001	< 0.001	-9.73 (-14.2, -5.28)	-13.9 (-18.9, -8.89)	-29.6 (-34.7, -24.6)
WHR	375	0.003	0.005	-6.14 (-11.8, -0.49)	-3.18 (-8.95, 2.59)	-10.1 (-15.9, -4.41)
Parity	596	< 0.001	0.002	-5.70 (-11.2, -0.20)	-5.82 (-10.4, -1.26)	-8.70 (-14.1, -3.27)
Visually Assessed % dense area
age	599	0.001	0.004	-1.69 (-6.13, 2.75)	-1.71 (-6.52, 3.10)	-8.34 (-13.1, -3.60)
weight	458	< 0.001	< 0.001	-6.87 (-11.7, -2.05)	-14.1 (-18.9, -9.29)	-24.8 (-29.5, -20.0)
BMI	456	< 0.001	< 0.001	-6.22 (-11.0, -1.46)	-12.5 (-17.2, -7.70)	-26.0 (-30.6, -21.3)
hip	374	< 0.001	< 0.001	-4.29 (-9.33, 0.76)	-8.80 (-14.7, -2.94)	-23.6 (-28.6, -18.5)
Waist	382	< 0.001	< 0.001	-3.21 (-8.91, 2.49)	-9.63 (-14.7, -4.53)	-21.1 (-26.4, -15.7)
Chest	391	< 0.001	< 0.001	-9.64 (-14.3, -4.93)	-13.3 (-18.6, -8.00)	-29.5 (-34.8, -24.2)
WHR	371	0.007	0.01	-5.51 (-11.4, 0.36)	-2.31 (-8.32, 3.71)	-9.81 (-15.8, -3.83)
Parity	588	< 0.001	< 0.001	-5.66 (-11.3, -0.05)	-6.41 (-11.1, -1.75)	-10.8 (-16.4, -5.31)
				Quartile 2	Quartile 3	Quartile 4
	N	P _trend	P _het	Coefficient (95% CI)	Coefficient (95% CI)	Coefficient (95% CI)
MRI dense volume (×10 ³ , log)
age	651	0.24	0.57	-0.05 (-0.18, 0.08)	-0.03 (-0.17, 0.12)	-0.10 (-0.25, 0.04)
weight	515	0.12	0.38	0.07 (-0.09, 0.23)	0.13 (-0.03, 0.29)	0.11 (-0.05, 0.28)
BMI	513	0.75	0.47	0.10 (-0.05, 0.26)	0.10 (-0.06, 0.26)	0.02 (-0.14, 0.19)
hip	425	0.072	0.13	0.12 (-0.04, 0.29)	0.21 (0.02, 0.40)	0.13 (-0.04, 0.31)
Waist	434	0.063	0.19	-0.03 (-0.21, 0.15)	0.12 (-0.04, 0.28)	0.13 (-0.05, 0.31)
Chest	445	0.021	0.034	0.07 (-0.09, 0.22)	0.25 (0.08, 0.42)	0.15 (-0.04, 0.33)
WHR	423	0.25	0.64	0.00 (-0.18, 0.18)	0.08 (-0.10, 0.26)	0.09 (-0.10, 0.27)
Parity	629	0.14	0.46	-0.13 (-0.31, 0.05)	-0.10 (-0.25, 0.04)	-0.11 (-0.29, 0.06)
Cumulus dense volume (×10 ³ )
age	607	0.35	0.21	-187 (-433, 59.0)	15.1 (-252, 283)	-201 (-464, 61.9)
weight	464	0.003	0.017	9.71 (-267, 286)	-233 (-509, 43.4)	-366 (-641, -92.1)
BMI	462	0.001	0.004	52.7 (-223, 328)	-150 (-426, 127)	-419 (-690, -148)
hip	378	< 0.001	< 0.001	95.6 (-181, 372)	47.4 (-274, 369)	-545 (-824, -266)
Waist	386	0.027	0.14	-12.2 (-322, 298)	-135 (-414, 143)	-323 (-613, -31.9)
Chest	397	0.003	< 0.001	77.1 (-187, 341)	79.5 (-219, 378)	-516 (-817, -216)
WHR	375	0.99	0.55	-83.7 (-387, 219)	122 (-187, 432)	-67.6 (-375, 240)
Parity	596	0.001	0.012	-287 (-601, 26.6)	-285 (-545, -25.1)	-447 (-756, -137)

N = number of women for whom data were available. P_trend and P_het are P-values for the tests of trend (1 df) and heterogeneity (3 df) respectively between quartiles. Coefficients are for each quartile of the variable relative to the lowest quartile.

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