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Table 1 Relationship between measures of breast density and eight continuous variables, by quartile

From: Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study

     Quartile 2 Quartile 3 Quartile 4
  N Ptrend Phet Coefficient
(95% CI)
Coefficient
(95% CI)
Coefficient
(95% CI)
MRI % dense volume (log)
age 655 < 0.001 < 0.001 -0.02 (-0.14, 0.11) -0.08 (-0.22, 0.06) -0.38 (-0.52, -0.25)
weight 519 < 0.001 < 0.001 -0.29 (-0.42, -0.16) -0.43 (-0.56, -0.29) -0.83 (-0.97, -0.70)
BMI 517 < 0.001 < 0.001 -0.22 (-0.35, -0.09) -0.48 (-0.61, -0.35) -0.86 (-0.99, -0.72)
hip 429 < 0.001 < 0.001 -0.17 (-0.31, -0.03) -0.29 (-0.45, -0.12) -0.68 (-0.84, -0.53)
Waist 438 < 0.001 < 0.001 -0.10 (-0.25, 0.06) -0.29 (-0.43, -0.14) -0.65 (-0.81, -0.49)
Chest 449 < 0.001 < 0.001 -0.22 (-0.36, -0.09) -0.37 (-0.52, -0.22) -0.86 (-1.01, -0.70)
WHR 427 0.006 0.032 -0.09 (-0.26, 0.08) -0.09 (-0.26, 0.08) -0.26 (-0.43, -0.09)
Parity 633 0.008 0.052 -0.19 (-0.36, -0.01) -0.19 (-0.33, -0.05) -0.22 (-0.39, -0.05)
Cumulus % dense area
age 607 0.003 0.004 -1.58 (-5.87, 2.71) -0.53 (-5.20, 4.14) -7.66 (-12.2, -3.08)
weight 464 < 0.001 < 0.001 -9.21 (-13.7, -4.72) -17.2 (-21.7, -12.7) -26.6 (-31.0, -22.1)
BMI 462 < 0.001 < 0.001 -7.97 (-12.4, -3.56) -15.7 (-20.1, -11.3) -27.6 (-32.0, -23.3)
hip 378 < 0.001 < 0.001 -5.59 (-10.4, -0.78) -10.7 (-16.3, -5.10) -24.4 (-29.3, -19.6)
Waist 386 < 0.001 < 0.001 -3.56 (-8.99, 1.86) -11.3 (-16.2, -6.47) -20.9 (-26.0, -15.8)
Chest 397 < 0.001 < 0.001 -9.73 (-14.2, -5.28) -13.9 (-18.9, -8.89) -29.6 (-34.7, -24.6)
WHR 375 0.003 0.005 -6.14 (-11.8, -0.49) -3.18 (-8.95, 2.59) -10.1 (-15.9, -4.41)
Parity 596 < 0.001 0.002 -5.70 (-11.2, -0.20) -5.82 (-10.4, -1.26) -8.70 (-14.1, -3.27)
Visually Assessed % dense area
age 599 0.001 0.004 -1.69 (-6.13, 2.75) -1.71 (-6.52, 3.10) -8.34 (-13.1, -3.60)
weight 458 < 0.001 < 0.001 -6.87 (-11.7, -2.05) -14.1 (-18.9, -9.29) -24.8 (-29.5, -20.0)
BMI 456 < 0.001 < 0.001 -6.22 (-11.0, -1.46) -12.5 (-17.2, -7.70) -26.0 (-30.6, -21.3)
hip 374 < 0.001 < 0.001 -4.29 (-9.33, 0.76) -8.80 (-14.7, -2.94) -23.6 (-28.6, -18.5)
Waist 382 < 0.001 < 0.001 -3.21 (-8.91, 2.49) -9.63 (-14.7, -4.53) -21.1 (-26.4, -15.7)
Chest 391 < 0.001 < 0.001 -9.64 (-14.3, -4.93) -13.3 (-18.6, -8.00) -29.5 (-34.8, -24.2)
WHR 371 0.007 0.01 -5.51 (-11.4, 0.36) -2.31 (-8.32, 3.71) -9.81 (-15.8, -3.83)
Parity 588 < 0.001 < 0.001 -5.66 (-11.3, -0.05) -6.41 (-11.1, -1.75) -10.8 (-16.4, -5.31)
     Quartile 2 Quartile 3 Quartile 4
  N P trend P het Coefficient
(95% CI)
Coefficient
(95% CI)
Coefficient
(95% CI)
MRI dense volume (×10 3 , log)
age 651 0.24 0.57 -0.05 (-0.18, 0.08) -0.03 (-0.17, 0.12) -0.10 (-0.25, 0.04)
weight 515 0.12 0.38 0.07 (-0.09, 0.23) 0.13 (-0.03, 0.29) 0.11 (-0.05, 0.28)
BMI 513 0.75 0.47 0.10 (-0.05, 0.26) 0.10 (-0.06, 0.26) 0.02 (-0.14, 0.19)
hip 425 0.072 0.13 0.12 (-0.04, 0.29) 0.21 (0.02, 0.40) 0.13 (-0.04, 0.31)
Waist 434 0.063 0.19 -0.03 (-0.21, 0.15) 0.12 (-0.04, 0.28) 0.13 (-0.05, 0.31)
Chest 445 0.021 0.034 0.07 (-0.09, 0.22) 0.25 (0.08, 0.42) 0.15 (-0.04, 0.33)
WHR 423 0.25 0.64 0.00 (-0.18, 0.18) 0.08 (-0.10, 0.26) 0.09 (-0.10, 0.27)
Parity 629 0.14 0.46 -0.13 (-0.31, 0.05) -0.10 (-0.25, 0.04) -0.11 (-0.29, 0.06)
Cumulus dense volume (×10 3 )
age 607 0.35 0.21 -187 (-433, 59.0) 15.1 (-252, 283) -201 (-464, 61.9)
weight 464 0.003 0.017 9.71 (-267, 286) -233 (-509, 43.4) -366 (-641, -92.1)
BMI 462 0.001 0.004 52.7 (-223, 328) -150 (-426, 127) -419 (-690, -148)
hip 378 < 0.001 < 0.001 95.6 (-181, 372) 47.4 (-274, 369) -545 (-824, -266)
Waist 386 0.027 0.14 -12.2 (-322, 298) -135 (-414, 143) -323 (-613, -31.9)
Chest 397 0.003 < 0.001 77.1 (-187, 341) 79.5 (-219, 378) -516 (-817, -216)
WHR 375 0.99 0.55 -83.7 (-387, 219) 122 (-187, 432) -67.6 (-375, 240)
Parity 596 0.001 0.012 -287 (-601, 26.6) -285 (-545, -25.1) -447 (-756, -137)
  1. N = number of women for whom data were available. Ptrend and Phet are P-values for the tests of trend (1 df) and heterogeneity (3 df) respectively between quartiles. Coefficients are for each quartile of the variable relative to the lowest quartile.