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Table 1 Cell lines arranged from most sensitive (low IC50) to least sensitive (high IC50)

From: PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

Cell line IC50value (nM) IC50standard error Breast cancer subtype ER status HER2 status
MDA-MB-175 4 0.4 Luminal Positive Normal
ZR-75-30 5 0.5 Luminal Positive Amplified
CAMA-1 8 0.4 Luminal Positive Normal
MDA-MB-134 13 1.3 Luminal Positive Normal
HCC-202 21 2.3 Luminal Positive Amplified
UACC-893 24 1.6 Luminal Positive Amplified
EFM-19 27 12.3 Luminal Positive Normal
SUM-190 28 1.3 Luminal Positive Amplified
EFM-192A 42 21.2 Luminal Positive Amplified
MDA-MB-361 44 4.1 Luminal Positive Amplified
HCC-1500 45 22.6 Luminal Positive Normal
HCC-1419 51 3.7 Luminal Positive Amplified
HCC-38 64 14.8 Basal Negative Normal
MDA-MB-415 64 6.6 Luminal Positive Normal
MCF-10A 92 0.1 n/a Negative Immortalized
UACC-812 96 4.6 Luminal Positive Amplified
HCC-2218 100 17.0 Luminal Positive Amplified
ZR-75-1 110 54.1 Luminal Positive Normal
MDA-MB-453 115 1.4 Luminal Negative Amplified
184A1 118 2.0 n/a Negative Immortalized
T47-D 127 15.0 Luminal Positive Normal
MCF-7 148 25.7 Luminal Positive Normal
BT-20 177 3.1 Basal Negative Normal
MDA-MB-435 201 7.5 Post-EMT Negative Normal
BT-474 240 64.5 Luminal Positive Amplified
SK-BR-3 300 83.0 Luminal Negative Amplified
KPL-1 327 64.3 Luminal Positive Normal
HCC-1143 359 99.7 Basal Negative Normal
MDA-MB-231 432 16.1 Post-EMT Negative Normal
HCC-1395 472 39.8 Post-EMT Negative Normal
SUM-225 503 55.7 Luminal Negative Amplified
Hs578t 524 12.3 Post-EMT Negative Normal
184B5 538 41.1 n/a Negative Immortalized
UACC-732 744 14.9 Luminal Positive Amplified
CAL-51 905 0.0 Post-EMT Negative Normal
BT-549 1,000 n/a Post-EMT Negative Normal
COLO-824 1,000 n/a Basal Negative Normal
DU4475 1,000 n/a Basal Negative Normal
HCC-1187 1,000 n/a Basal Negative Normal
HCC-1569 1,000 n/a Post-EMT Negative Amplified
HCC-1806 1,000 n/a Basal Negative Normal
HCC-1937 1,000 n/a Post-EMT Negative Normal
HCC-1954 1,000 n/a Basal Negative Amplified
HCC-70 1,000 n/a Basal Negative Normal
MDA-MB-436 1,000 n/a Post-EMT Negative Normal
MDA-MB-157 1,000 n/a Post-EMT Negative Normal
MDA-MB-468 1,000 n/a Basal Negative Normal
  1. Included are molecular subtype and estrogen receptor (ER) and HER2 status. Cell lines representing the luminal ER-positive subtype were most sensitive to the growth inhibition effects of PD 0332991. n/a, not applicable; Post-EMT, cell lines classified as representing breast cancers that had undergone an epithelial-to-mesenchymal transition.