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Table 1 Cell lines arranged from most sensitive (low IC50) to least sensitive (high IC50)

From: PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

Cell line

IC50value (nM)

IC50standard error

Breast cancer subtype

ER status

HER2 status

MDA-MB-175

4

0.4

Luminal

Positive

Normal

ZR-75-30

5

0.5

Luminal

Positive

Amplified

CAMA-1

8

0.4

Luminal

Positive

Normal

MDA-MB-134

13

1.3

Luminal

Positive

Normal

HCC-202

21

2.3

Luminal

Positive

Amplified

UACC-893

24

1.6

Luminal

Positive

Amplified

EFM-19

27

12.3

Luminal

Positive

Normal

SUM-190

28

1.3

Luminal

Positive

Amplified

EFM-192A

42

21.2

Luminal

Positive

Amplified

MDA-MB-361

44

4.1

Luminal

Positive

Amplified

HCC-1500

45

22.6

Luminal

Positive

Normal

HCC-1419

51

3.7

Luminal

Positive

Amplified

HCC-38

64

14.8

Basal

Negative

Normal

MDA-MB-415

64

6.6

Luminal

Positive

Normal

MCF-10A

92

0.1

n/a

Negative

Immortalized

UACC-812

96

4.6

Luminal

Positive

Amplified

HCC-2218

100

17.0

Luminal

Positive

Amplified

ZR-75-1

110

54.1

Luminal

Positive

Normal

MDA-MB-453

115

1.4

Luminal

Negative

Amplified

184A1

118

2.0

n/a

Negative

Immortalized

T47-D

127

15.0

Luminal

Positive

Normal

MCF-7

148

25.7

Luminal

Positive

Normal

BT-20

177

3.1

Basal

Negative

Normal

MDA-MB-435

201

7.5

Post-EMT

Negative

Normal

BT-474

240

64.5

Luminal

Positive

Amplified

SK-BR-3

300

83.0

Luminal

Negative

Amplified

KPL-1

327

64.3

Luminal

Positive

Normal

HCC-1143

359

99.7

Basal

Negative

Normal

MDA-MB-231

432

16.1

Post-EMT

Negative

Normal

HCC-1395

472

39.8

Post-EMT

Negative

Normal

SUM-225

503

55.7

Luminal

Negative

Amplified

Hs578t

524

12.3

Post-EMT

Negative

Normal

184B5

538

41.1

n/a

Negative

Immortalized

UACC-732

744

14.9

Luminal

Positive

Amplified

CAL-51

905

0.0

Post-EMT

Negative

Normal

BT-549

1,000

n/a

Post-EMT

Negative

Normal

COLO-824

1,000

n/a

Basal

Negative

Normal

DU4475

1,000

n/a

Basal

Negative

Normal

HCC-1187

1,000

n/a

Basal

Negative

Normal

HCC-1569

1,000

n/a

Post-EMT

Negative

Amplified

HCC-1806

1,000

n/a

Basal

Negative

Normal

HCC-1937

1,000

n/a

Post-EMT

Negative

Normal

HCC-1954

1,000

n/a

Basal

Negative

Amplified

HCC-70

1,000

n/a

Basal

Negative

Normal

MDA-MB-436

1,000

n/a

Post-EMT

Negative

Normal

MDA-MB-157

1,000

n/a

Post-EMT

Negative

Normal

MDA-MB-468

1,000

n/a

Basal

Negative

Normal

  1. Included are molecular subtype and estrogen receptor (ER) and HER2 status. Cell lines representing the luminal ER-positive subtype were most sensitive to the growth inhibition effects of PD 0332991. n/a, not applicable; Post-EMT, cell lines classified as representing breast cancers that had undergone an epithelial-to-mesenchymal transition.