Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

Table 2 Single SNP analysis results within significant linkage disequilibrium blocks for BRCA1 carriers

	LD block^a	SNP	Genotype	n	Hazard ratio	95% confidence interval	Pfor trend
IRS1	1	rs1801278	GG	990
			GA, AA	115	0.82	0.58, 1.17
	1	rs13306465	GG	999
			GA, AA	97	1.44	1.07, 1.94
	1	rs1801123	AA	823
			AG, GG	279	1.37	1.11, 1.69
IGF1R	11	rs8038415	CC	281
			CT	536	1.11	0.88, 1.41
			TT	270	1.40	1.07, 1.83	0.015
	11	rs17847201	GG	350
			GA	581	0.87	0.69, 1.10
			AA	154	0.77	0.56, 1.05	0.091

IRS1, insulin-like growth factor receptor substrate 1; IGF1R, insulin-like growth factor-1 receptor. ^aLinkage disequilibrium (LD) block was defined by pairwise LD coefficient D' ≥ 0.90.

ISSN: 1465-542X