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Table 2 Single SNP analysis results within significant linkage disequilibrium blocks for BRCA1 carriers

From: Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

  LD blocka SNP Genotype n Hazard ratio 95% confidence interval Pfor trend
IRS1 1 rs1801278 GG 990    
    GA, AA 115 0.82 0.58, 1.17  
  1 rs13306465 GG 999    
    GA, AA 97 1.44 1.07, 1.94  
  1 rs1801123 AA 823    
    AG, GG 279 1.37 1.11, 1.69  
IGF1R 11 rs8038415 CC 281    
    CT 536 1.11 0.88, 1.41  
    TT 270 1.40 1.07, 1.83 0.015
  11 rs17847201 GG 350    
    GA 581 0.87 0.69, 1.10  
    AA 154 0.77 0.56, 1.05 0.091
  1. IRS1, insulin-like growth factor receptor substrate 1; IGF1R, insulin-like growth factor-1 receptor. aLinkage disequilibrium (LD) block was defined by pairwise LD coefficient D' ≥ 0.90.