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Table 1 Participant characteristics and incidence of breast cancer diagnosis by BRCA status

From: Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

  BRCA1 BRCA2
Characteristic n Cases Incidence ratea n Cases Incidence ratea
Total 1,122 433 26.94 (19.79, 34.10) 543 238 25.03 (18.71, 31.36)
Raceb       
   Caucasian (non-Jewish, non-Hispanic) 774 283 26.72 (19.58, 33.86) 381 176 27.70 (20.63, 34.77)
   African American 29 14 39.37 (28.13, 50.61) 13 6 25.28 (18.47, 32.09)
   Jewish 245 98 24.08 (17.95, 30.22) 119 43 17.39 (13.19, 21.60)
   Caucasian Hispanic 35 17 43.97 (30.46, 57.47) 9 5 33.07 (22.50, 43.65)
   Other 31 16 38.66 (28.28, 49.05) 19 6 20.68 (15.61, 25.74)
Ovarian cancer       
   Yes 128 26 20.86 (11.70, 30.01) 30 5 18.90 (8.84, 28.96)
   No 994 407 27.78 (20.46, 35.10) 513 233 25.43 (19.10, 31.77)
Prophylactic ovarian surgery       
   Yes before breast cancer 282 44 24.88 (17.53, 32.23) 108 18 27.64 (19.07, 36.21)
   Yes after breast cancer 167 167 -- 99 99 --
   No bilateral prophylactic oophorectomy 671 221 28.07 (20.72, 35.42) 336 121 25.29 (18.93, 31.64)
Clinic Site       
   Medical University Vienna 204 84 39.26 (29.31, 49.21) 62 37 28.19 (20.83, 35.55)
   Beth Israel 8 4 30.58 (22.39, 38.76) 15 6 125.51 (35.71, 215.31)
   Baylor University Medical Center --Dallas 14 10 69.46 (50.29, 88.63) 1 1 14.59 (10.21, 18.97)
   City of Hope 56 25 43.30 (31.79, 54.81) 28 17 54.17 (40.17, 68.18)
   Creighton 155 65 28.49 (21.39, 35.59) 40 23 55.87 (42.83, 68.91)
   Dana Farber 88 41 36.22 (27.27, 45.18) 32 11 27.20 (21.04, 33.37)
   NorthShore University Health System 35 16 26.55 (19.62, 33.47) 21 9 17.77 (13.57, 21.97)
   Fox Chase Cancer Center 40 10 14.41 (9.97, 18.86) 28 9 18.18 (13.32, 23.04)
   Georgetown University 42 13 21.35 (16.23, 26.47) 16 3 21.64 (16.24, 27.05)
   University of California, Los Angeles 43 18 36.95 (25.09, 48.81) 17 7 13.62 (10.03, 17.21)
   Mayo Clinic 60 17 18.57 (14.53, 22.61) 31 10 30.38 (24.01, 36.75)
   University of Texas Health Science Center at San Antonio 35 17 40.18 (27.33, 53.02) 32 13 11.67 (9.00, 14.34)
   University of Chicago 34 15 52.84 (36.66, 69.02) 18 9 18.73 (14.47, 22.98)
   University of Pennsylvania 147 56 24.08 (17.37, 30.78) 92 44 51.62 (43.58, 59.66)
   University of Utahc 115 30 14.85 (10.70, 19.00) 87 27 27.54 (19.36, 35.72)
   Women's College Hospital, Toronto 46 12 16.24 (11.72, 20.76) 23 12 44.56 (33.11, 56.02)
Aged    44.7 ± 11.2    48.1 ± 13
  1. aData presented as incidence per 1,000 women per year (95% confidence interval). Rates have been externally standardized to the age distribution of the study cohort at the time of genetic testing. bFive subjects missing race information. cNow at University of California, Irvine. dData presented as mean ± standard deviation.