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Table 1 Participant characteristics and incidence of breast cancer diagnosis by BRCA status

From: Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

 

BRCA1

BRCA2

Characteristic

n

Cases

Incidence ratea

n

Cases

Incidence ratea

Total

1,122

433

26.94 (19.79, 34.10)

543

238

25.03 (18.71, 31.36)

Raceb

      

   Caucasian (non-Jewish, non-Hispanic)

774

283

26.72 (19.58, 33.86)

381

176

27.70 (20.63, 34.77)

   African American

29

14

39.37 (28.13, 50.61)

13

6

25.28 (18.47, 32.09)

   Jewish

245

98

24.08 (17.95, 30.22)

119

43

17.39 (13.19, 21.60)

   Caucasian Hispanic

35

17

43.97 (30.46, 57.47)

9

5

33.07 (22.50, 43.65)

   Other

31

16

38.66 (28.28, 49.05)

19

6

20.68 (15.61, 25.74)

Ovarian cancer

      

   Yes

128

26

20.86 (11.70, 30.01)

30

5

18.90 (8.84, 28.96)

   No

994

407

27.78 (20.46, 35.10)

513

233

25.43 (19.10, 31.77)

Prophylactic ovarian surgery

      

   Yes before breast cancer

282

44

24.88 (17.53, 32.23)

108

18

27.64 (19.07, 36.21)

   Yes after breast cancer

167

167

--

99

99

--

   No bilateral prophylactic oophorectomy

671

221

28.07 (20.72, 35.42)

336

121

25.29 (18.93, 31.64)

Clinic Site

      

   Medical University Vienna

204

84

39.26 (29.31, 49.21)

62

37

28.19 (20.83, 35.55)

   Beth Israel

8

4

30.58 (22.39, 38.76)

15

6

125.51 (35.71, 215.31)

   Baylor University Medical Center --Dallas

14

10

69.46 (50.29, 88.63)

1

1

14.59 (10.21, 18.97)

   City of Hope

56

25

43.30 (31.79, 54.81)

28

17

54.17 (40.17, 68.18)

   Creighton

155

65

28.49 (21.39, 35.59)

40

23

55.87 (42.83, 68.91)

   Dana Farber

88

41

36.22 (27.27, 45.18)

32

11

27.20 (21.04, 33.37)

   NorthShore University Health System

35

16

26.55 (19.62, 33.47)

21

9

17.77 (13.57, 21.97)

   Fox Chase Cancer Center

40

10

14.41 (9.97, 18.86)

28

9

18.18 (13.32, 23.04)

   Georgetown University

42

13

21.35 (16.23, 26.47)

16

3

21.64 (16.24, 27.05)

   University of California, Los Angeles

43

18

36.95 (25.09, 48.81)

17

7

13.62 (10.03, 17.21)

   Mayo Clinic

60

17

18.57 (14.53, 22.61)

31

10

30.38 (24.01, 36.75)

   University of Texas Health Science Center at San Antonio

35

17

40.18 (27.33, 53.02)

32

13

11.67 (9.00, 14.34)

   University of Chicago

34

15

52.84 (36.66, 69.02)

18

9

18.73 (14.47, 22.98)

   University of Pennsylvania

147

56

24.08 (17.37, 30.78)

92

44

51.62 (43.58, 59.66)

   University of Utahc

115

30

14.85 (10.70, 19.00)

87

27

27.54 (19.36, 35.72)

   Women's College Hospital, Toronto

46

12

16.24 (11.72, 20.76)

23

12

44.56 (33.11, 56.02)

Aged

  

44.7 ± 11.2

  

48.1 ± 13

  1. aData presented as incidence per 1,000 women per year (95% confidence interval). Rates have been externally standardized to the age distribution of the study cohort at the time of genetic testing. bFive subjects missing race information. cNow at University of California, Irvine. dData presented as mean ± standard deviation.
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Breast Cancer Research

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