Haplotype presence for insulin-like growth factor receptor substrate 1 and insulin-like growth factor 1. Estimated hazard ratios (Est HR) associated with haplotype presence for (a) insulin-like growth factor receptor substrate 1 (IRS1) and (b) insulin-like growth factor 1 (IGF1). Linkage blocks were defined as in Figure 2 (pairwise linkage disequilibrium coefficient D' ≥ 0.90). Estimates were stratified by BRCA status (left column, BRCA1; right column, BRCA2) and adjusted for birth cohort and ethnicity as well as first pregnancy, prophylactic oophorectomy, and diagnosis of ovarian cancer as time-dependent covariates. LD Grp, linkage disequilibrium group; Geno/Haplo, genotype/haplotype; Freq, frequency.