Haplotype presence for insulin-like growth factor binding proteins. Estimated hazard ratios (Est HR) associated with haplotype presence for (a) insulin-like growth factor binding protein (IGFBP)-1, (b) IGFBP2, and (c) IGFBP5. Linkage blocks were defined as pairwise linkage disequilibrium coefficient D' ≥ 0.90. Estimates were stratified by BRCA status (left column, BRCA1; right column, BRCA2) and adjusted for birth cohort and ethnicity as well as first pregnancy, prophylactic oophorectomy, and diagnosis of ovarian cancer as time-dependent covariates. LD Grp, linkage disequilibrium group; Geno/Haplo, genotype/haplotype; Freq, frequency.