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Table 1 Patient characteristics at the time of primary diagnosis of breast cancer

From: Comparative evaluation of cell-free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer

 

Patients (%)

LOH (%)§

DTC (%)$

Total

81

27 (33.5)

32 (39.5)

Age

56 years (range 33-81)

 

24 (41)

Family history

  

4 (31)

   negative

58 (73)

21 (36)

4 (50)

   positive

13 (17)

5 (39)

 

   unknown

8 (10)

1 (13)

28 (37)

Patient subgroup

   

   M0

76 (94)

27 (36)

 

   M1

5 (6)

0 (0)

4 (80)

Tumor size

   

   pT1

33 (41)

14 (42)

11 (33)

   pT2

39 (48)

12 (31)

17 (44)

   pT3-4

9 (11)

1 (11)

4 (44)

Nodal status

   

   pN0

49 (62)

19 (39)

21 (43)

   pN1-2

30 (38)

8 (27)

10 (33)

Histology

   

   Ductal

60 (75)

23 (38)

20 (33)

   Lobular

10 (12.5)

3 (30)

6 (60)

   Others*

10 (12.5)

1 (10)

6 (60)

Grading

   

   I-II

51 (65)

23 (45)

21 (41)

   III

28 (35)

4 (14)

10 (36)

ER status

   

   negative

23 (28.5)

6 (26)

9 (39)

   positive

58 (71.5)

21 (36)

23 (40)

PR status

   

   negative

29 (36)

8 (28)

8 (28)

   positive

52 (64)

19 (37)

24 (46)

CEA

   

   negative

69 (86)

25 (36)

27 (39)

   positive

11 (14)

2 (18)

5 (46)

CA15-3

   

   negative

67 (84)

25 (37)

27 (40)

   positive

13 (16)

2 (15)

5 (39)

Therapy

   

   BCT

45 (56)

20 (44)

14 (31)

   Ablation

36 (44)

7 (22)

18 (50)

  1. *n = 5 tumors were characterized as mixed ductal/lobular carcinomas of the breast; in five tumors histology was unknown. Among these five tumors were three cases of inflammatory breast cancer and one case of a carcinoma sarcoma of the breast with unknown histological subtype.
  2. §total loss of heterozygosity (LOH) detected at all six markers in blood
  3. $ disseminated tumor cells (DTC) detected in bone marrow
  4. BCT = breast conserving therapy; CEA = carcino embryonal antigen; ER = estrogen receptor; PR = progesterone receptor.