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Table 2 IC50 values of DZNep on BRCA1-deficient vs. BRCA1-reconstituted mammary tumor cells

From: BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Cell line nM DZNep (SEM)
BRCA1-proficient  
KP-6.3 3523 (463)
BRCA1-reconstituted  
KB1PR-3.12 E3 1954 (744)
KB1PR-3.12 F4 829 (331)
BRCA1-deficient  
KB1P-3.12 135 (13)
KB1P40.1 187 (33)
Ratio (BRCA1-reconst. vs. deficient) 8.7*
Significance 0.003
  1. Note: Values between brackets represent the standard error of the mean (SEM) of at least three independent experiments. Ratio: Average half maximal inhibitory concentration (IC50) values of 3-deazaneplanocin A (DZNep) for the K 14cre; B rca 1F/F; p 53F/F(KB1P) lines were compared with average IC50 values of the KB1P lines. *Significance: P < 0.01 (t-test).