BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Table 1 IC₅₀ values of DZNep and TSA on BRCA1-proficient vs. BRCA1-deficient mammary tumor cells

Note: Values between brackets represent the standard error of the mean (SEM) of at least three independent experiments. Ratio: Average half maximal inhibitory concentration (IC₅₀) values of 3-deazaneplanocin A (DZNep) and trichostatin A (TSA) for the K 14cre;Brca1^w.t/w.t; p 53^F/F(KP) lines were compared with average IC₅₀ values of the K 14cre; B rca 1^F/F; p 53^F/F(KB1P) lines. *Significance: P < 0.01 (t-test).

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