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Table 1 IC50 values of DZNep and TSA on BRCA1-proficient vs. BRCA1-deficient mammary tumor cells

From: BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Cell line nM DZNep (SEM) nM TSA (SEM)
BRCA1-proficient   
KP-3.33 3202 (284) 27 (1.2)
KP-6.3 3467 (277) 35 (1.5)
KP-7.7 2163 (63) 25 (3.8)
BRCA1-deficient   
KB1P-3.12 154 (14) 26 (2.4)
KB1P-30.3 163 (13) 17 (0.6)
KB1P-40.1 171 (9) 36 (3.4)
Ratio (KP/KB1P) 18.1* 1.1
Significance < 0.0001 0.5
  1. Note: Values between brackets represent the standard error of the mean (SEM) of at least three independent experiments. Ratio: Average half maximal inhibitory concentration (IC50) values of 3-deazaneplanocin A (DZNep) and trichostatin A (TSA) for the K 14cre;Brca1w.t/w.t; p 53F/F(KP) lines were compared with average IC50 values of the K 14cre; B rca 1F/F; p 53F/F(KB1P) lines. *Significance: P < 0.01 (t-test).