An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer

Table 1 Univariate association of pathway deregulation with disease-free survival

Pathway	Overall	LumA	LumB	Her2	Basal
Ras	0.64	0.081	0.6	0.75	0.87
Myc	0.0033	0.92	0.0091	0.037	0.7
E2F3	1.8E-04	0.55	0.0044	0.13	0.13
Bcat	0.22	0.43	0.084	0.64	0.56
Src	0.85	0.79	0.29	0.32	0.7
NP63	0.93	0.21	0.83	0.73	0.19
PI3K	0.72	0.12	0.82	0.84	0.15
p53mut	6.0E-06	0.15	0.0014	0.037	0.77
Her1	1.5E-04	0.12	0.077	0.11	0.98
ER	3.9E-04	0.15	0.001	0.083	0.078
Proliferation	3.0E-05	0.088	0.0035	0.046	0.76

P values of the pathway coefficient when predicting disease-free survival (Cox proportional hazard P values). The pathways with significant relapse-free survival associations are indicated in italics; these were tested across all patients, and across all patients within each subtype separately.

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