Pathway-activation status patterns are characteristic of intrinsic subtypes. (a) Heat maps of scaled pathway-activation scores in which the subjects are ordered according to their predicted subtype. The pathway-activation status of different pathways is displayed for the combined dataset, with strong pathway activation displayed by red, average status by black, and low to absent pathway activation by green. (b) Box-and-whisker plot showing pathway activation as a function of subtype displayed for the combined dataset. (c) Comparison of pathway activation as a function of subtype in the two datasets.