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Table 3 Univariate and multivariate analyses of gene-expression prognostic factors (as continuous variables) for locoregional recurrences

From: Tumor aromatase expression as a prognostic factor for local control in young breast cancer patients after breast-conserving treatment

Gene expression by quantitative rt-PCR (continuous variables) Univariate analysis Multivariate analysis
  HR (RR)
[95% CI]
P HR (RR)
[95% CI]
P
Estrogen receptor-α 1.22 [0.90–1.66] 0.15   
Estrogen receptor-β 0.61 [0.39–0.95] 0.04   0.54
Progesterone receptor 1.13 [0.88–1.45] 0.32   
HER1 0.65 [0.37–1.13] 0.10   0.72
HER2 0.89 [0.64–1.25] 0.49   
HER3 1.06 [0.55–2.02] 0.87   
HER4 1.22 [0.91–1.63] 0.14   
MKI 67 0.89 [0.61–1.30] 0.56   
Cyclin E1 0.81 [0.48–1.36] 0.43   
Cyclin E2 0.75 [0.49–1.14] 0.18   
GATA 3 1.61 [0.95–2.73] 0.04 1.49 [0.92–2.39] 0.06
IGF1R 1.41 [0.93–2.14] 0.13   
NCoR 0.90 [0.38–2.15] 0.82   
NCoA3/AIB1 0.51 [0.21–1.22] 0.14   
CYP19 (aromatase) 0.48 [0.28–0.80] 0.003 0.49 [0.29–0.82] 0.003
Skp2 0.52 [0.23–1.17] 0.10   0.18
CAF-1 p150 1.00 [0.48–2.12] 1.00   
CAF-1 p60 1.00 [0.97–1.03] 0.94   
  1. RR = relative risk for locoregional recurrence calculated with the nonparametric Cox model; CI = confidence interval; HER = human epidermal receptor. Because of lack of prognostic values of the clinical variables in univariate analysis, none was entered in the multivariate analysis.