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Table 3 Univariate and multivariate analyses of gene-expression prognostic factors (as continuous variables) for locoregional recurrences

From: Tumor aromatase expression as a prognostic factor for local control in young breast cancer patients after breast-conserving treatment

Gene expression by quantitative rt-PCR (continuous variables)

Univariate analysis

Multivariate analysis

 

HR (RR)

[95% CI]

P

HR (RR)

[95% CI]

P

Estrogen receptor-α

1.22 [0.90–1.66]

0.15

  

Estrogen receptor-β

0.61 [0.39–0.95]

0.04

 

0.54

Progesterone receptor

1.13 [0.88–1.45]

0.32

  

HER1

0.65 [0.37–1.13]

0.10

 

0.72

HER2

0.89 [0.64–1.25]

0.49

  

HER3

1.06 [0.55–2.02]

0.87

  

HER4

1.22 [0.91–1.63]

0.14

  

MKI 67

0.89 [0.61–1.30]

0.56

  

Cyclin E1

0.81 [0.48–1.36]

0.43

  

Cyclin E2

0.75 [0.49–1.14]

0.18

  

GATA 3

1.61 [0.95–2.73]

0.04

1.49 [0.92–2.39]

0.06

IGF1R

1.41 [0.93–2.14]

0.13

  

NCoR

0.90 [0.38–2.15]

0.82

  

NCoA3/AIB1

0.51 [0.21–1.22]

0.14

  

CYP19 (aromatase)

0.48 [0.28–0.80]

0.003

0.49 [0.29–0.82]

0.003

Skp2

0.52 [0.23–1.17]

0.10

 

0.18

CAF-1 p150

1.00 [0.48–2.12]

1.00

  

CAF-1 p60

1.00 [0.97–1.03]

0.94

  
  1. RR = relative risk for locoregional recurrence calculated with the nonparametric Cox model; CI = confidence interval; HER = human epidermal receptor. Because of lack of prognostic values of the clinical variables in univariate analysis, none was entered in the multivariate analysis.