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Table 6 Percentage mammographic density as a function of single-nucleotide polymorphism: additive modelsa

From: Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women

  Entire analytic sample (N = 451) Whites only (N = 219)
  Age, race/ethnicity-study siteb, parity, smoking, body mass index Age, study site, parity, smoking, body mass index
LOCUS β SD P value β SD P value
17-β HSD       
   rs615942 G -0.68 1.02 0.50 -0.68 1.55 0.66
   rs592389 G -1.01 1.02 0.32 -0.59 1.56 0.71
   rs2830 A 1.05 1.01 0.30 0.63 1.56 0.69
ESR1       
   rs9340799 A 1.58 1.22 0.20 3.11 1.77 0.08
   rs2234693 T 1.44 1.06 0.18 4.08 1.61 0.01
   rs728524 A 3.35 1.77 0.06 -9.14 6.50 0.16
   rs3798577 T 1.01 1.05 0.34 -0.36 1.65 0.83
ESR2       
   rs1256030 C 0.79 1.10 0.47 0.76 1.64 0.64
   rs1255998 C -0.42 1.30 0.75 -2.38 2.61 0.36
   rs1256049 G -1.02 1.53 0.51 -2.28 4.34 0.60
CYP1A1       
   rs2606345 C -1.32 1.40 0.34 -1.00 1.69 0.56
   rs4646903 T 1.49 1.19 0.21 1.34 2.25 0.55
   rs1531163 A -0.33 1.60 0.84 -4.51 3.70 0.23
   rs1048943 A 0.20 1.55 0.90 1.19 4.05 0.77
CYP1B1       
   rs1800440 A 0.72 1.58 0.65 1.73 1.84 0.35
   rs162555 T 0.52 1.64 0.75 0.45 2.01 0.82
   rs1056836 C -0.37 1.22 0.78 -1.39 1.62 0.39
CYP19A1       
   rs700519 C 1.59 1.72 0.36 -3.46 4.00 0.39
   rs2414096 G 0.77 1.11 0.49 2.75 1.74 0.12
CYP194947c A 0.99 0.96 0.30 2.67 1.62 0.10
   rs1008805 T -0.02 1.12 0.99 -0.65 1.66 0.70
   rs2446405 T 0.81 1.20 0.50 -3.02 2.05 0.14
   rs936306 C -0.92 1.25 0.46 -3.67 2.12 0.09
   rs2445759 G -3.47 2.36 0.14 -5.19 2.86 0.07
   rs749292 G 0.67 1.08 0.53 2.83 1.67 0.09
  1. aReference allele was the allele with the higher frequency in the overall analytic sample and is indicated in the first column for each SNP. bBecause each site recruited a specific racial/ethnic group in addition to non-Hispanic whites, a combined variable was created for race/ethnicity and study site. cNo corresponding dbsnp rs number; commonly referred to as CYP194947.