Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women

Breast Cancer Research

Table 6 Percentage mammographic density as a function of single-nucleotide polymorphism: additive models^a

	Entire analytic sample (N = 451)			Whites only (N = 219)
	Age, race/ethnicity-study site^b, parity, smoking, body mass index			Age, study site, parity, smoking, body mass index
LOCUS	β	SD	P value	β	SD	P value
17-β HSD
rs615942 G	-0.68	1.02	0.50	-0.68	1.55	0.66
rs592389 G	-1.01	1.02	0.32	-0.59	1.56	0.71
rs2830 A	1.05	1.01	0.30	0.63	1.56	0.69
ESR1
rs9340799 A	1.58	1.22	0.20	3.11	1.77	0.08
rs2234693 T	1.44	1.06	0.18	4.08	1.61	0.01
rs728524 A	3.35	1.77	0.06	-9.14	6.50	0.16
rs3798577 T	1.01	1.05	0.34	-0.36	1.65	0.83
ESR2
rs1256030 C	0.79	1.10	0.47	0.76	1.64	0.64
rs1255998 C	-0.42	1.30	0.75	-2.38	2.61	0.36
rs1256049 G	-1.02	1.53	0.51	-2.28	4.34	0.60
CYP1A1
rs2606345 C	-1.32	1.40	0.34	-1.00	1.69	0.56
rs4646903 T	1.49	1.19	0.21	1.34	2.25	0.55
rs1531163 A	-0.33	1.60	0.84	-4.51	3.70	0.23
rs1048943 A	0.20	1.55	0.90	1.19	4.05	0.77
CYP1B1
rs1800440 A	0.72	1.58	0.65	1.73	1.84	0.35
rs162555 T	0.52	1.64	0.75	0.45	2.01	0.82
rs1056836 C	-0.37	1.22	0.78	-1.39	1.62	0.39
CYP19A1
rs700519 C	1.59	1.72	0.36	-3.46	4.00	0.39
rs2414096 G	0.77	1.11	0.49	2.75	1.74	0.12
CYP194947^c A	0.99	0.96	0.30	2.67	1.62	0.10
rs1008805 T	-0.02	1.12	0.99	-0.65	1.66	0.70
rs2446405 T	0.81	1.20	0.50	-3.02	2.05	0.14
rs936306 C	-0.92	1.25	0.46	-3.67	2.12	0.09
rs2445759 G	-3.47	2.36	0.14	-5.19	2.86	0.07
rs749292 G	0.67	1.08	0.53	2.83	1.67	0.09

^aReference allele was the allele with the higher frequency in the overall analytic sample and is indicated in the first column for each SNP. ^bBecause each site recruited a specific racial/ethnic group in addition to non-Hispanic whites, a combined variable was created for race/ethnicity and study site. ^cNo corresponding dbsnp rs number; commonly referred to as CYP194947.

ISSN: 1465-542X