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Table 5 Percentage mammographic density as a function of single-nucleotide polymorphism: recessive modelsa

From: Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women

 

Entire analytic sample (N = 451)

Whites only (N = 219)

 

Age, race/ethnicity-study site,b parity, smoking, body mass index

Age, study site, parity, smoking, body mass index

Locus

β

SD

P value

β

SD

P value

17-β HSD

      

   rs615942 G

-0.18

1.73

0.92

0.78

2.55

0.76

   rs592389 A

-0.81

1.71

0.64

0.97

2.55

0.70

   rs2830 A

1.75

1.65

0.29

2.69

2.59

0.30

ESR1

      

   rs9340799 A

4.40

2.79

0.12

6.67

3.50

0.06

   rs2234693 T

3.37

1.81

0.06

7.04

2.67

0.01

   rs728524 A

1.43

5.33

0.79

N/A

N/A

N/A

   rs3798577 T

3.04

1.79

0.09

1.14

2.75

0.68

ESR2

      

   rs1256030 C

0.72

2.10

0.73

0.80

2.94

0.79

   rs1255998 C

-0.14

2.25

0.95

-11.59

11.92

0.33

   rs1256049 G

-5.58

3.21

0.08

-6.98

16.85

0.68

CYP1A1

      

   rs2606345 C

-0.21

2.15

0.92

-0.09

2.32

0.97

   rs4646903 A

0.83

2.45

0.73

-1.11

6.45

0.99

   rs1531163 A

0.09

4.47

0.98

-5.50

16.87

0.74

   rs1048943 A

1.14

3.99

0.77

N/A

N/A

N/A

CYP1B1

      

   rs1800440 A

-2.29

3.92

0.56

-1.35

4.50

0.76

   rs162555 T

9.36

4.62

0.04

8.23

5.45

0.13

   rs1056836 C

2.48

2.51

0.33

1.37

3.07

0.66

CYP19A1

      

   rs700519 G

-4.59

6.12

0.45

N/A

N/A

N/A

   rs2414096 G

-0.83

1.94

0.67

1.33

2.81

0.64

CYP194947¶ A

1.30

1.68

0.44

3.93

2.83

0.17

   rs1008805 T

-3.56

2.24

0.11

-2.36

3.07

0.44

   rs2446405 T

1.99

2.31

0.39

-4.96

5.78

0.39

   rs936306 C

-6.17

2.82

0.03

-16.36

5.96

0.01

   rs2445759 G

-7.30

9.18

0.43

-10.36

11.98

0.39

   rs749292 G

0.40

1.93

0.84

3.53

2.98

0.24

  1. aReference allele was the allele with the higher frequency in the overall analytic sample and is indicated in the first column for each SNP.
  2. bBecause each site recruited a specific racial/ethnic group in addition to non-Hispanic whites, a combined variable was created for race/ethnicity and study site.