Skip to main content

Advertisement

Table 5 Percentage mammographic density as a function of single-nucleotide polymorphism: recessive modelsa

From: Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women

  Entire analytic sample (N = 451) Whites only (N = 219)
  Age, race/ethnicity-study site,b parity, smoking, body mass index Age, study site, parity, smoking, body mass index
Locus β SD P value β SD P value
17-β HSD       
   rs615942 G -0.18 1.73 0.92 0.78 2.55 0.76
   rs592389 A -0.81 1.71 0.64 0.97 2.55 0.70
   rs2830 A 1.75 1.65 0.29 2.69 2.59 0.30
ESR1       
   rs9340799 A 4.40 2.79 0.12 6.67 3.50 0.06
   rs2234693 T 3.37 1.81 0.06 7.04 2.67 0.01
   rs728524 A 1.43 5.33 0.79 N/A N/A N/A
   rs3798577 T 3.04 1.79 0.09 1.14 2.75 0.68
ESR2       
   rs1256030 C 0.72 2.10 0.73 0.80 2.94 0.79
   rs1255998 C -0.14 2.25 0.95 -11.59 11.92 0.33
   rs1256049 G -5.58 3.21 0.08 -6.98 16.85 0.68
CYP1A1       
   rs2606345 C -0.21 2.15 0.92 -0.09 2.32 0.97
   rs4646903 A 0.83 2.45 0.73 -1.11 6.45 0.99
   rs1531163 A 0.09 4.47 0.98 -5.50 16.87 0.74
   rs1048943 A 1.14 3.99 0.77 N/A N/A N/A
CYP1B1       
   rs1800440 A -2.29 3.92 0.56 -1.35 4.50 0.76
   rs162555 T 9.36 4.62 0.04 8.23 5.45 0.13
   rs1056836 C 2.48 2.51 0.33 1.37 3.07 0.66
CYP19A1       
   rs700519 G -4.59 6.12 0.45 N/A N/A N/A
   rs2414096 G -0.83 1.94 0.67 1.33 2.81 0.64
CYP194947 A 1.30 1.68 0.44 3.93 2.83 0.17
   rs1008805 T -3.56 2.24 0.11 -2.36 3.07 0.44
   rs2446405 T 1.99 2.31 0.39 -4.96 5.78 0.39
   rs936306 C -6.17 2.82 0.03 -16.36 5.96 0.01
   rs2445759 G -7.30 9.18 0.43 -10.36 11.98 0.39
   rs749292 G 0.40 1.93 0.84 3.53 2.98 0.24
  1. aReference allele was the allele with the higher frequency in the overall analytic sample and is indicated in the first column for each SNP.
  2. bBecause each site recruited a specific racial/ethnic group in addition to non-Hispanic whites, a combined variable was created for race/ethnicity and study site.