From: Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women
Entire analytic sample (N = 451) | Whites only (N = 219) | |||||
---|---|---|---|---|---|---|
Age, race/ethnicity-study site,^{b} parity, smoking, body mass index | Age, study site, parity, smoking, body mass index | |||||
Locus | β | SD | P value | β | SD | P value |
17-β HSD | ||||||
rs615942 G | -0.18 | 1.73 | 0.92 | 0.78 | 2.55 | 0.76 |
rs592389 A | -0.81 | 1.71 | 0.64 | 0.97 | 2.55 | 0.70 |
rs2830 A | 1.75 | 1.65 | 0.29 | 2.69 | 2.59 | 0.30 |
ESR1 | ||||||
rs9340799 A | 4.40 | 2.79 | 0.12 | 6.67 | 3.50 | 0.06 |
rs2234693 T | 3.37 | 1.81 | 0.06 | 7.04 | 2.67 | 0.01 |
rs728524 A | 1.43 | 5.33 | 0.79 | N/A | N/A | N/A |
rs3798577 T | 3.04 | 1.79 | 0.09 | 1.14 | 2.75 | 0.68 |
ESR2 | ||||||
rs1256030 C | 0.72 | 2.10 | 0.73 | 0.80 | 2.94 | 0.79 |
rs1255998 C | -0.14 | 2.25 | 0.95 | -11.59 | 11.92 | 0.33 |
rs1256049 G | -5.58 | 3.21 | 0.08 | -6.98 | 16.85 | 0.68 |
CYP1A1 | ||||||
rs2606345 C | -0.21 | 2.15 | 0.92 | -0.09 | 2.32 | 0.97 |
rs4646903 A | 0.83 | 2.45 | 0.73 | -1.11 | 6.45 | 0.99 |
rs1531163 A | 0.09 | 4.47 | 0.98 | -5.50 | 16.87 | 0.74 |
rs1048943 A | 1.14 | 3.99 | 0.77 | N/A | N/A | N/A |
CYP1B1 | ||||||
rs1800440 A | -2.29 | 3.92 | 0.56 | -1.35 | 4.50 | 0.76 |
rs162555 T | 9.36 | 4.62 | 0.04 | 8.23 | 5.45 | 0.13 |
rs1056836 C | 2.48 | 2.51 | 0.33 | 1.37 | 3.07 | 0.66 |
CYP19A1 | ||||||
rs700519 G | -4.59 | 6.12 | 0.45 | N/A | N/A | N/A |
rs2414096 G | -0.83 | 1.94 | 0.67 | 1.33 | 2.81 | 0.64 |
CYP194947^{¶} A | 1.30 | 1.68 | 0.44 | 3.93 | 2.83 | 0.17 |
rs1008805 T | -3.56 | 2.24 | 0.11 | -2.36 | 3.07 | 0.44 |
rs2446405 T | 1.99 | 2.31 | 0.39 | -4.96 | 5.78 | 0.39 |
rs936306 C | -6.17 | 2.82 | 0.03 | -16.36 | 5.96 | 0.01 |
rs2445759 G | -7.30 | 9.18 | 0.43 | -10.36 | 11.98 | 0.39 |
rs749292 G | 0.40 | 1.93 | 0.84 | 3.53 | 2.98 | 0.24 |