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Table 2 Univariate Cox proportional hazards analysis

From: Presence of HER4 associates with increased sensitivity to Herceptin™ in patients with metastatic breast cancer

  Parameter Overall survival
   HR 95% CI P
FISH HER1 0.45 0.12 to 1.787 0.256
  HER3 1.14 0.34 to 37.51 0.943
  HER4 <0.01 <0.01 to 0.33 0.011
  ERα 1.19 0.71 to 2.00 0.511
IHC HER1 1.62 0.67 to 3.92 0.282
  HER2 shedding 1.36 0.69 to 2.70 0.376
  phospho-HER2 0.20 0.05 to 0.86 0.030
  HER3 1.01 0.42 to 2.44 0.982
  HER4 0.43 0.22 to 0.85 0.016
  Ki-67 1.36 0.67 to 2.77 0.397
  ER 1.00 0.92 to 1.08 0.979
  PR 0.98 0.91 to 1.06 0.647
  p27 Kip1 0.42 0.21 to 0.84 0.014
Others Grading 2.01 0.83 to 4.87 0.123
  Age (<50 vs. ≥ 50 years) 1.34 0.68 to 2.67 0.401
  1. Overall survival was defined from beginning of Herceptin™ treatment. Hazard ratios (HR), confidence intervals (CI) and P values of investigated parameters dependent on overall survival. CI with lower and upper limits. Data in bold define significant results.
  2. ER = oestrogen receptor; FISH = fluorescence in situ hybridisation; HER = human epidermal growth factor receptor; IHC = immunohistochemistry.