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Table 1 Aromatase mRNA levels and preferential utilization of multiple exons 1 of the aromatase gene

From: Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years

Exon 1 group

Tissue category

 
 

EldCa

EldNorm

ContCa

ContNorm

P valuea

 

n (%)

Aromatase mRNA ± SEMb

n (%)

Aromatase mRNA ± SEMb

n (%)

Aromatase mRNA ± SEMb

n (%)

Aromatase mRNA ± SEMb

 

'd > c'

20 (53%)

26.5 ± 4.49

  

1 (3%)

22.8

  

0.8610 NS

   dc

5 (13%)

35.5 ± 14.4

       

   dcb

1 (3%)

18.8

       

   dbc

7 (18%)

21.8 ± 5.79

       

   bdc

7 (18%)

25.8 ± 5.98

  

1 (3%)

22.8

   

'd'

16 (42%)

12.0 ± 3.28

18 (53%)

4.67 ± 1.13

2 (6%)

10.9 ± 7.75

  

0.0941 NS

   d

12 (32%)

13.7 ± 4.21

15 (44%)

4.13 ± 1.30

     

   db

2 (5%)

6.05 ± 0.350

1 (3%)

9.20

     

   bd

2 (5%)

8.25 ± 7.15

2 (6%)

6.45 ± 0.950

2 (6%)

10.9 ± 7.75

   

'c > d'

  

12 (35%)

15.3 ± 4.54

4 (11%)

8.56 ± 4.57

2 (7%)

2.98 ± 1.67

0.4445 NS

   cd

  

1 (3%)

10.5

3 (9%)

4.44 ± 2.80

2 (7%)

2.98 ± 1.67

 

   cdb

  

3 (9%)

11.2 ± 9.32

     

   cbd

  

5 (15%)

20.5 ± 8.85

1 (3%)

20.9

   

   bcd

  

3 (9%)

12.6 ± 8.18

     

'c'

2 (5%)

13.1 ± 11.6

3 (9%)

3.37 ± 2.56

19 (54%)

10.8 ± 2.82

14 (48%)

7.26 ± 1.96

0.5534 NS

   c

2 (5%)

13.1 ± 11.6

3 (9%)

3.37 ± 2.56

10 (29%)

9.07 ± 4.34

5 (17%)

2.04 ± 0.645

 

   cb

    

4 (11%)

17.2 ± 7.01

5 (17%)

9.33 ± 3.54

 

   bc

    

5 (14%)

9.12 ± 3.30

4 (14%)

11.2 ± 4.26

 

'b' = b

  

1 (3%)

1.10

9 (26%)

5.21 ± 1.54

13 (45%)

1.22 ± 0.339

0.0222 S

Total

38 (100%)

19.7 ± 2.97

34 (100%)

8.22 ± 1.91

35 (100%)

9.45 ± 1.75

29 (100%)

4.26 ± 1.09

< 0.0001 S

P valuec

0.0511 NS

0.0444 S

0.4871 NS

0.0209 S

 
  1. Comparison of aromatase mRNA levels according to preferential utilization of multiple exons 1 of the aromatase gene in carcinomas from the elderly (EldCa), normal tissues from the elderly (EldNorm), carcinomas from controls (ContCa), and normal tissues from controls (ContNorm). For example, dcb means exon 1d > 1c > 1b. aComparison of aromatase mRNA levels according to tissue categories in each exon 1 group or in total (one-factor analysis of variance). bValues are presented in amol/mgRNA. cComparison of aromatase mRNA levels according to exon 1 groups in each tissue category (one-factor analysis of variance). NS, not significant; S, significant; SEM, standard error of the mean.
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Breast Cancer Research

ISSN: 1465-542X

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