Table 3 Association between FOXA1 and GATA3 expression and the immunohistochemical markers in infiltrative breast carcinomas
Variable | N | FOXA1-negative (%) | FOXA1-positive (%) | P value | n | GATA3-negative (%) | GATA3-positive (%) | P value |
|---|---|---|---|---|---|---|---|---|
EGFR | 223 | 203 | ||||||
Positive | 13 | 10 (7.6) | 3 (3.3) | 0.171 | 11 | 11 (10.4) | 0 (0) | 0.001 |
Negative | 210 | 121 (92.4) | 89 (96.7) | 192 | 95 (89.6) | 97 (100) | ||
P-cadherin | 220 | 202 | ||||||
Positive | 75 | 53 (40.8) | 22 (24.4) | 0.012 | 71 | 52 (49.1) | 19 (19.8) | <0.0001 |
Negative | 145 | 77 (59.2) | 68 (75.6) | 131 | 54 (50.9) | 77 (80.2) | ||
Cytokeratin 5 | 224 | 204 | ||||||
Positive | 50 | 36 (27.5) | 14 (15) | 0.027 | 48 | 39 (36.4) | 9 (9.3) | <0.0001 |
Negative | 174 | 95 (72.5) | 79 (85) | 156 | 68 (63.6) | 88 (90.7) | ||
Cytokeratin 14 | 219 | 201 | ||||||
Positive | 14 | 13 (10.1) | 1 (1.5) | 0.007 | 14 | 14 (13.3) | 0 (0) | 0.0002 |
Negative | 205 | 116 (89.9) | 89 (98.9) | 187 | 91 (86.7) | 96 (100) | ||
Vimentin | 203 | 194 | ||||||
Positive | 34 | 28 (23.1) | 6 (7.3) | 0.003 | 32 | 26 (25) | 6 (6.7) | 0.0006 |
Negative | 169 | 93 (76.9) | 76 (92.7) | 162 | 78 (75) | 84 (93.3) | ||
FOXA1 | - | - | - | - | 201 | |||
Positive | - | - | - | 82 | 16 (15.4) | 66 (68) | <0.0001 | |
Negative | - | - | - | 119 | 88 (84.6) | 31 (32) | ||
GATA-3 | 201 | - | - | - | - | |||
Positive | 97 | 31 (26.1) | 66 (80.5) | <0.0001 | - | - | - | |
Negative | 104 | 88 (73.9) | 16 (19.5) | - | - | - | ||
Subtype | 202 | 187 | ||||||
Luminal A | 125 | 56 (47) | 69 (83.1) | <0.0001 | 114 | 36 (36.7) | 78 (87.7) | <0.0001 |
Luminal B | 8 | 4 (3.4) | 4 (4.8) | 8 | 5 (5.1) | 3 (3.4) | ||
HER-2 | 27 | 23 (19.3) | 4 (4.8) | 26 | 24 (24.5) | 2 (2.2) | ||
Basal | 42 | 36 (30.3) | 6 (7.3) | 39 | 33 (33.7) | 6 (6.7) |