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Table 3 Association between FOXA1 and GATA3 expression and the immunohistochemical markers in infiltrative breast carcinomas

From: Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours

Variable N FOXA1-negative (%) FOXA1-positive (%) P value n GATA3-negative (%) GATA3-positive (%) P value
EGFR 223     203    
   Positive 13 10 (7.6) 3 (3.3) 0.171 11 11 (10.4) 0 (0) 0.001
   Negative 210 121 (92.4) 89 (96.7)   192 95 (89.6) 97 (100)  
P-cadherin 220     202    
   Positive 75 53 (40.8) 22 (24.4) 0.012 71 52 (49.1) 19 (19.8) <0.0001
   Negative 145 77 (59.2) 68 (75.6)   131 54 (50.9) 77 (80.2)  
Cytokeratin 5 224     204    
   Positive 50 36 (27.5) 14 (15) 0.027 48 39 (36.4) 9 (9.3) <0.0001
   Negative 174 95 (72.5) 79 (85)   156 68 (63.6) 88 (90.7)  
Cytokeratin 14 219     201    
   Positive 14 13 (10.1) 1 (1.5) 0.007 14 14 (13.3) 0 (0) 0.0002
   Negative 205 116 (89.9) 89 (98.9)   187 91 (86.7) 96 (100)  
Vimentin 203     194    
   Positive 34 28 (23.1) 6 (7.3) 0.003 32 26 (25) 6 (6.7) 0.0006
   Negative 169 93 (76.9) 76 (92.7)   162 78 (75) 84 (93.3)  
FOXA1 - - - - 201    
   Positive - - -   82 16 (15.4) 66 (68) <0.0001
   Negative - - -   119 88 (84.6) 31 (32)  
GATA-3 201     - - - -
   Positive 97 31 (26.1) 66 (80.5) <0.0001 - - -  
   Negative 104 88 (73.9) 16 (19.5)   - - -  
Subtype 202     187    
   Luminal A 125 56 (47) 69 (83.1) <0.0001 114 36 (36.7) 78 (87.7) <0.0001
   Luminal B 8 4 (3.4) 4 (4.8)   8 5 (5.1) 3 (3.4)  
   HER-2 27 23 (19.3) 4 (4.8)   26 24 (24.5) 2 (2.2)  
   Basal 42 36 (30.3) 6 (7.3)   39 33 (33.7) 6 (6.7)  
  1. FOXA-1, forkhead box A1; GATA-3, GATA binding protein 3; EGFR, epidermal growth factor receptor; HER-2, human epidermal growth factor receptor 2.