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Table 2 Association between FOXA1 and GATA3 expression and the clinicopathological features of the infiltrative breast carcinomas

From: Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours

Variable N FOXA1-negative (%) FOXA1-positive (%) P value n GATA3-negative (%) GATA3-positive (%) P value
Tumour size (mm) 209 35.2 ± 24.0 (126) 26.8 ± 15.7 (83) 0.005 191 34.4 ± 25.2 (100) 28.6 ± 16.7 (91) 0.064
Lymphovascular invasion 203     185    
   Present 97 67 (69.1) 30 (30.9) 0.012 92 49 (53.3) 43 (46.7) 0.829
   Absent 106 55 (51.9) 51 (48.1)   93 51 (54.8) 42 (45.2)  
Lymph node stage 203     185    
   Negative 106 55 (51.9) 51 (48.1) 0.022 93 51 (54.8) 42 (45.2) 0.166
   1 to 3 lymph nodes 49 31 (63.3) 18 (36.7)   46 20 (43.5) 26 (56.5)  
   >3 lymph nodes 48 36 (75) 12 (25)   46 29 (63) 17 (37)  
Grade 224     204    
   Grade I 44 25 (56.8) 19 (43.2) 0.001 40 24 (60) 16 (40) 0.013
   Grade II 105 50 (47.6) 55 (52.4)   96 40 (41.7) 56 (58.3)  
   Grade III 75 56 (74.7) 19 (25.3)   68 43 (63.2) 25 (36.8)  
Histology 224     204    
   IDC 188 113 (60.1) 75 (39.9) 0.119 171 91 (53.2) 80 (46.8) 0.104
   ILC 6 2 (33.3) 4 (66.7)   6 0 (0) 6 (100)  
   Tubular 1 1 (100) 0 (0)   1 0 (0) 1 (100)  
   Medullary 7 5 (71.4) 2 (28.6)   7 5 (71.4) 2 (28.6)  
   Other 19 7 (36.8) 12 (63.2)   16 9 (56.2) 7 (43.8)  
   Mixed 3 3 (100) 0 (0)   3 2 (66.7) 1 (33.3)  
Nottingham Prognostic Index 190     172    
   <3.4 44 18 (40.9) 26 (59.1) 0.002 40 19 (47.5) 21 (52.5) 0.293
   3.4 to 5.4 96 59 (61.5) 37 (38.5)   86 44 (51.2) 42 (48.8)  
   >5.4 50 38 (76) 12 (24)   46 29 (63) 17 (37)  
ERα 224     204    
   Positive 133 60 (45.1) 73 (54.9) <0.0001 122 41 (33.6) 81 (66.4) <0.0001
   Negative 91 71 (78) 20 (22)   82 66 (80.9) 16 (19.5)  
PR 223     204    
   Positive 83 33 (39.7) 50 (60.3) <0.0001 74 22 (29.7) 52 (70.3) <0.0001
   Negative 140 98 (70) 42 (30)   130 85 (65.4) 45 (34.6)  
HER-2 220     201    
   Positive 35 27 (77.1) 8 (22.9) 0.017 34 29 (85.3) 5 (14.7) <0.0001
   Negative 185 103 (55.7) 82 (44.3)   167 77 (46.1) 90 (53.9)  
  1. FOXA-1, forkhead box A1; GATA-3, GATA binding protein 3; IDC, invasive ductal carcinoma (not otherwise specified); ILC, invasive lobular carcinoma; ERα, oestrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor 2.