Skip to main content

Advertisement

Table 2 Comparison of plasma biomarkers and mammographic measures in Afro-Caribbean women compared with Caucasian women

From: Sex steroids, growth factors and mammographic density: a cross-sectional study of UK postmenopausal Caucasian and Afro-Caribbean women

  Adjustmenta
  Age and batch Age, batch and BMI Age, batch, BMI and breast cancer risk factorsb
Plasma biomarkerc    
   Leptin (ng/ml)d 6.8 (4.8, 8.9)**** 3.2 (1.7, 4.7)**** 3.6 (1.9, 5.2)****
   Oestradiol (pmol/l) 1.31 (1.12, 1.52)**** 1.11 (0.96, 1.29) 1.11 (0.94, 1.31)
   Free oestradiol (pmol/l) 1.39 (1.17, 1.65)**** 1.11 (0.95, 1.30) 1.11 (0.94, 1.32)
   Oestrone (pmol/l) 1.13 (1.01, 1.27)** 1.05 (0.93, 1.18) 1.05 (0.93, 1.19)
   SHBG (nmol/l) 0.86 (0.78, 0.96)*** 0.98 (0.89, 1.08) 0.96 (0.86, 1.07)
   Testosterone (nmol/l) 0.94 (0.80, 1.11) 0.88 (0.74, 1.03) 0.86 (0.72, 1.03)
   Prolactin (mIU/l) 1.02 (0.90, 1.16) 1.04 (0.91, 1.19) 1.00 (0.87, 1.16)
   IGF-I (ng/ml) 1.09 (1.00, 1.19)** 1.13 (1.03, 1.24)*** 1.12 (1.01, 1.24)**
   IGF-I:IGFBP-3 molar ratio 1.13 (1.04, 1.23)*** 1.20 (1.10, 1.30)*** 1.20 (1.10, 1.32)***
   IGF-II (ng/ml) 0.83 (0.77, 0.89)**** 0.82 (0.76, 0.89)**** 0.82 (0.76, 0.90)****
   IGF-II:IGFBP-3 molar ratio 0.86 (0.80, 0.92)**** 0.87 (0.81, 0.94)** 0.89 (0.82, 0.96)**
   IGFBP-3 (ng/ml) 0.96 (0.91, 1.02)* 0.94 (0.89, 1.00)** 0.93 (0.87, 0.99)**
Mammographic measurese    
   Mammographic density (%) -5.4 (-7.8, -3.0)**** -2.5 (-5.1, 0.2)* -0.8 (-3.7, 2.2)
   Dense area (cm2) -2.7 (-6.9, 1.4) -1.9 (-6.4, 2.7) 0.7 (-4.4, 5.8)
   Nondense area (cm2) 50.5 (33.2, 67.8)*** 19.6 (7.7, 31.5)*** 15.7 (3.1, 28.3)**
   Total breast area (cm2) 48.7 (31.3, 66.0)**** 18.7 (6.3, 31.1)*** 17.0 (3.6, 30.5)**
  1. IGF, insulin-like growth factor; IGFBP, IGF binding protein; SHBG, sex hormone binding globulin. aAdjustment made for age at blood collection and processing batch (or age at mammography) in all models, in addition to listed factors. bAge at menarche, parity, age at first birth, smoking, age at menopause. cData presented as ratio (95% confidence interval) of mean levels (Afro-Caribbean:Caucasian). dArithmetic scale (absolute differences reported as leptin did not need to be log-transformed). eData presented as difference (95% confidence interval) in means (Afro-Caribbean-Caucasian). *P < 0.1, **P < 0.05, ***P < 0.01, ****P < 0.001.