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Table 1 Distributions of breast cancer risk factors and breast cancer biomarkers by ethnic group

From: Sex steroids, growth factors and mammographic density: a cross-sectional study of UK postmenopausal Caucasian and Afro-Caribbean women

 

Caucasian women (n = 152)

Afro-Caribbean women (n = 118)

Lifestyle breast cancer risk factorsa

  

   Age at mammography (years)

57.8 (3.3)

58.1 (3.6)

   Age arrived in UK (years)

-

20.9 (9.0)

   Age at menarche (years)

12.7 (1.5)

13.5 (2.0)

   Percentage nulliparous

22.2

6.0

   Age at first birth (years)

24.4 (5.8)

22.2 (5.2)

   Age at menopause (years)

50.1 (4.8)

48.3 (5.4)

   Body mass index (kg/m2)

26.2 (5.4)

29.4 (5.4)

   Percentage previous hormone therapy use (ever)

35.5

24.6

   Percentage previous oral contraceptive use (ever)

72.2

40.4

   Percentage alcohol drinkers

86.1

57.4

   Percentage current smokers

13.3

4.3

   Percentage family history of breast cancer

17.8

11.9

Mammographic measuresb

  

   Mammographic density (%)

16.2 (8.9 to 24.5)

8.3 (4.3 to 19.8)

   Dense area (cm2)

21.2 (11.9 to 35.7)

17.3 (8.4 to 31.3)

   Nondense area (cm2)

116.9 (86.7 to 160.0)

167.9 (115.3 to 235.9)

   Total breast area (cm2)

141.5 (108.1 to 193.3)

195.2 (140.2 to 261.5)

Plasma biomarkersc

  

   Leptin (ng/ml)

12.3 (11.1, 13.5)d

19.1 (17.5, 20.7)c

   Oestradiol (pmol/l)

21.7 (19.6, 23.9)

29.0 (25.6, 32.9)

   Free oestradiol (pmol/l)

0.31 (0.27, 0.34)

0.44 (0.38, 0.50)

   Oestrone (pmol/l)

72.9 (68.0, 78.2)

82.2 (74.9, 90.3)

   Sex hormone binding globulin (nmol/l)

49.2 (46.1, 52.4)

42.5 (39.1, 46.2)

   Testosterone (nmol/l)

0.95 (0.86, 1.05)

0.89 (0.78, 1.02)

   Prolactin (mIU/l)

192 (177, 209)

193 (174, 213)

   IGF-I (ng/ml)

144 (137, 152)

157 (146, 168)

   IGF-I:IGFBP3 molar ratio

0.175 (0.166, 0.184)

0.199 (0.187, 0.213)

   IGF-II (ng/ml)

896 (857, 938)

742 (698, 789)

   IGF-II:IGFBP3 molar ratio

1.09 (1.04, 1.13)

0.94 (0.89, 1.00)

   IGFBP3 (ng/ml)

4286 (4125, 4452)

4097 (3920, 4282)

  1. IGF, insulin-like growth factor; IGFBP, IGF binding protein. aData presented as mean (standard deviation) or percentage. bData presented as median (25th to 75th percentiles). cData presented as geometric mean (95% confidence interval). dArithmetic mean (variable was not log transformed).
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Breast Cancer Research

ISSN: 1465-542X

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