|  | 6 mo | 12 mo | 18 mo | 24 mo | ||||
---|---|---|---|---|---|---|---|---|---|
 |  | Mean ± SEM | P | Mean ± SEM | P | Mean ± SEM | P | Mean ± SEM | P |
Cholesterol change | E | 11.5 ± 5.6 | 0.046 | 14.4 ± 5 | 0.005 | 15.3 ± 7 | 0.037 | 8.9 ± 7.4 | NS |
 | O | 16.8 ± 4.7 | 0.001 | 21.6 ± 4.1 | <0.001 | 24 ± 5.3 | <0.001 | 17 ± 6 | 0.009 |
HDL change | E | -4.3 ± 1.8 | 0.025 | -3 ± 2.3 | NS | -6.5 ± 2.6 | 0.024 | -8.3 ± 2.1 | 0.001 |
 | O | 2.2 ± 1.5 | NS | 1.7 ± 1.4 | NS | 1.5 ± 1.2 | NS | 1.1 ± 1.9 | NS |
LDL change | E | 24.3 ± 6.3 | 0.001 | 20.1 ± 6.3 | 0.004 | 22.7 ± 9.5 | 0.030 | 32.1 ± 8.1 | 0.001 |
 | O | 19.8 ± 5.7 | 0.002 | 22.3 ± 4.9 | <0.001 | 30.4 ± 6.2 | <0.001 | 23 ± 8.4 | 0.015 |
Total TRG change | E | -24.1 ± 7.8 | 0.004 | -32.2 ± 7.6 | <0.001 | -26.8 ± 9.3 | 0.008 | -20.7 ± 9.6 | 0.040 |
 | O | -13.7 ± 6.1 | 0.031 | -17.6 ± 7.6 | 0.026 | -9.4 ± 7.2 | NS | -19.8 ± 9 | 0.038 |