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Table 7 Clinicopathological parameters in relation to EDN3 promoter methylation
| Variables | EDN3 promoter | |||
|---|---|---|---|---|
| Numbera | Unmethylated (percentage) | Methylated (percentage) | P valueb | |
| Total | 128 | 39 (30.5) | 89 (69.5) | |
| Clinicopathological factors | ||||
| Age at diagnosis | ||||
| ≤ 59 years | 64 | 22 (34) | 42 (66) | 0.443 |
| > 59 years | 64 | 17 (29) | 47 (71) | |
| Tumour sizec | ||||
| pT1 | 44 | 15 (34) | 29 (66) | 0.680 |
| pT2 to pT4 | 72 | 21 (29) | 51 (71) | |
| Lymph node statusc | ||||
| pN0 | 57 | 16 (28) | 41 (72) | 0.676 |
| pN1 to pN3 | 51 | 17 (33) | 34 (67) | |
| Histological grade | ||||
| G1 and G2 | 68 | 18 (26) | 50 (74) | 0.310 |
| G3 | 49 | 18 (37) | 31 (63) | |
| Histological type | ||||
| Ductal | 103 | 32 (31) | 71 (69) | 0.849 |
| Lobular | 15 | 5 (33) | 10 (67) | |
| Other | 6 | 1 (17) | 5 (83) | |
| Immunohistochemistry | ||||
| Oestrogen receptor | ||||
| Negative (IRSd ≤ 2) | 33 | 11 (33) | 22 (67) | 0.655 |
| Positive (IRS > 2) | 85 | 24 (28) | 61 (72) | |
| Progesterone receptor | ||||
| Negative (IRSd ≤ 2) | 33 | 11 (33) | 22 (67) | 0.655 |
| Positive (IRS > 2) | 85 | 24 (28) | 61 (72) | |
