Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer

Breast Cancer Research

Table 6 Multivariate Cox regression analysis of clinicopathological factors potentially influencing breast cancer-specific survival, including EDN3 protein expression

Variable	Value	P value	Hazard ratio (HR)	95% confidence interval of HR
				Lower	Upper
Age
Continuous		0.005^a	1.04^a	1.01^a	1.06^a
pT
pT1	0		1.00
pT2 to pT4	1	0.109	1.87	0.87	4.04
pN
pN0	0		1.00
pN1 to pN3	1	0.002^a	3.12^a	1.53^a	6.33^a
Grade
G1 and G2	0		1.00
G3	1	0.013^a	2.17^a	1.18^a	3.99^a
EDN3 expression
High	0		1.00
Low	1	0.025^a	1.98^a	1.09^a	3.61^a

The variables were categorised according to Tables 4 and 5, except for age (continuous). ^aSignificant data. EDN3, endothelin-3.

ISSN: 1465-542X