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Table 4 Summary of step 1 of the stepwise analysis of the ER, PR, and HER2/neu signatures

From: MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neureceptor status in breast cancer

Rank MicroRNA Chromosomal location Validated mRNA targets Mean squared error Median accuracy (%)
ER status
1 miR-342 14q32.2, intronic - 0.132 84
2 miR-520g 19q13.42, intergenic - 0.198 73
3 miR-107 10q23.31, intronic - 0.200 73
4 miR-149 2q37.3, intronic - 0.201 69
5 miR-520g-h 19q13.42, intergenic - 0.203 73
6 miR-155 21q21.3, exon AGTR1, AID, TP53INPI 0.208 70
7 miR-30c 1p34.2, intronic - 0.210 67
8 miR-382 14q32.31, intergenic - 0.211 67
PR status
1 miR-520g 19q13.42, intergenic - 0.180 83.3
2 miR-520d 19q13.42, intergenic - 0.181 83.3
3 let-7d 9q22.32, intronic SMC1A 0.185 67
4 miR-328 16q22.1, intronic CD44, BCRP 0.189 83.3
5 miR-373 19q13.41intergenic E-Cadherin, lats2 CSDC2, CD44, RAD23B 0.189 83.3
6 miR-217 2p16.1, intergenic   0.196 67
7 miR-504 Xq26.3, intronic   0.198 67
8 miR-485-3p 14q32.31, intergenic   0.201 83.3
HER2/neu status
1 miR-520d 19q13.42, intergenic   0.109 87.5
2 miR-30b 8q24.22intergenic   0.111 83.3
3 miR-217 2p16.1, intergenic   0.114 83.3
4 miR-363 Xq26.2, intergenic   0.115 83.3
5 miR-383 8p22, intronic   0.115 83.3
6 miR-377 14q32.31, intergenic   0.120 87.5
7 miR-130a 11q12.1, intergenic GAX, HOXA5 0.121 83.3
8 miR-422a 15q22.31, intergenic   0.122 83.3
  1. ER, oestrogen receptor; PR, progesterone receptor; HER2/neu, v-erb-b2 erythroblastic leukaemia viral oncogene homolog 2 receptors.