MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neureceptor status in breast cancer

Table 4 Summary of step 1 of the stepwise analysis of the ER, PR, and HER2/neu signatures

Rank	MicroRNA	Chromosomal location	Validated mRNA targets	Mean squared error	Median accuracy (%)
ER status
1	miR-342	14q32.2, intronic	-	0.132	84
2	miR-520g	19q13.42, intergenic	-	0.198	73
3	miR-107	10q23.31, intronic	-	0.200	73
4	miR-149	2q37.3, intronic	-	0.201	69
5	miR-520g-h	19q13.42, intergenic	-	0.203	73
6	miR-155	21q21.3, exon	AGTR1, AID, TP53INPI	0.208	70
7	miR-30c	1p34.2, intronic	-	0.210	67
8	miR-382	14q32.31, intergenic	-	0.211	67
PR status
1	miR-520g	19q13.42, intergenic	-	0.180	83.3
2	miR-520d	19q13.42, intergenic	-	0.181	83.3
3	let-7d	9q22.32, intronic	SMC1A	0.185	67
4	miR-328	16q22.1, intronic	CD44, BCRP	0.189	83.3
5	miR-373	19q13.41intergenic	E-Cadherin, lats2 CSDC2, CD44, RAD23B	0.189	83.3
6	miR-217	2p16.1, intergenic		0.196	67
7	miR-504	Xq26.3, intronic		0.198	67
8	miR-485-3p	14q32.31, intergenic		0.201	83.3
HER2/neu status
1	miR-520d	19q13.42, intergenic		0.109	87.5
2	miR-30b	8q24.22intergenic		0.111	83.3
3	miR-217	2p16.1, intergenic		0.114	83.3
4	miR-363	Xq26.2, intergenic		0.115	83.3
5	miR-383	8p22, intronic		0.115	83.3
6	miR-377	14q32.31, intergenic		0.120	87.5
7	miR-130a	11q12.1, intergenic	GAX, HOXA5	0.121	83.3
8	miR-422a	15q22.31, intergenic		0.122	83.3

ER, oestrogen receptor; PR, progesterone receptor; HER2/neu, v-erb-b2 erythroblastic leukaemia viral oncogene homolog 2 receptors.

ISSN: 1465-542X