High at stem-like stage | Low at stem-like stage | Unchanged |
---|---|---|
Normal breast-like (ER-negative): 10 genes, none of which (0%) changed in stem-like stage | ||
0 genes | 0 genes | 10 genes |
Fhl1 – cell differentiation | ||
Cd36 – cell adhesion | ||
Itga7 – cell adhesion | ||
Leprotl1 – unknown | ||
Gpx3 – oxidation reduction | ||
Gpd1 – oxidation reduction | ||
Aoc3 – oxidation reduction | ||
Lpl – lipid catabolic process | ||
Aqp7 – transport | ||
Cidec – apoptosis | ||
Her2+ (ER-negative): four genes, one of which (25%) changed in stem-like stage | ||
1 gene | 0 genes | 3 genes |
Traf4 – regulation of apoptosis | Erbb2 – cell proliferation | |
Grb7 – signal transduction | ||
Smarce1 – chromatin modification | ||
Luminal A (ER-positive, p53 mut): 13 genes, three of which (23%) changed in stem-like stage | ||
0 genes | 3 genes | 10 genes |
ERα – regulation of transcription | Gata3 – regulation of transcription | |
Myo6 – regulation of transcription | Foxa1 – regulation of transcription | |
Xbp1 – regulation of transcription | Aff3 – regulation of transcription | |
Npnt – cell adhesion | ||
Anxa9 – cell – cell adhesion | ||
Gpr160 – signal transduction | ||
Slc39a6 – ion transport | ||
Tff3 – defense response | ||
Acadsb – lipid metabolic process | ||
Nat1 – metabolic process | ||
Luminal C (ER-positive, p53 mut): eight genes, six of which (75%) changed in stem-like stage | ||
5 genes | 1 genes | 2 genes |
Mybl2 – regulation of transcription | Ggh – glutamine metabolic process | Ywhaz – protein targeting |
Ybx1 – transcription | Sqle – oxidation reduction | |
Tfrc – endocytosis | ||
Ebna1bp2 – unknown function | ||
Kif23 – cell cycle | ||
Basal like (ER-negative, p53 mut): 15 genes, nine of which (60%) changed in stem-like stage | ||
5 genes | 4 genes | 6 genes |
Cdh3 – cell adhesion | Trim29 – transcription | Tnni2 – regulation of transcription |
Lamc2 – cell adhesion | Slpi – serine – type endopeptidase inhibitor activity | Nfib – regulation of transcription |
Krt17 – epidermis development | Galnt3 – metabolic process | Capn6 – proteolysis |
Krt5 – epidermis development | Sox9 – transcription/regulation of cell proliferation | Dmd – peptide biosynthetic process |
Cxcl1 – negative regulation of cell proliferation | Tgfb2 – apoptosis | |
Fabp7 – regulation of cell proliferation |