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Table 5 Correlation of mouse mammary stem-like gene expression and breast subtype signatures

From: Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression

High at stem-like stage

Low at stem-like stage

Unchanged

Normal breast-like (ER-negative): 10 genes, none of which (0%) changed in stem-like stage

0 genes

0 genes

10 genes

  

Fhl1 – cell differentiation

  

Cd36 – cell adhesion

  

Itga7 – cell adhesion

  

Leprotl1 – unknown

  

Gpx3 – oxidation reduction

  

Gpd1 – oxidation reduction

  

Aoc3 – oxidation reduction

  

Lpl – lipid catabolic process

  

Aqp7 – transport

  

Cidec – apoptosis

Her2+ (ER-negative): four genes, one of which (25%) changed in stem-like stage

1 gene

0 genes

3 genes

Traf4 – regulation of apoptosis

 

Erbb2 – cell proliferation

  

Grb7 – signal transduction

  

Smarce1 – chromatin modification

Luminal A (ER-positive, p53 mut): 13 genes, three of which (23%) changed in stem-like stage

0 genes

3 genes

10 genes

 

ERα – regulation of transcription

Gata3 – regulation of transcription

 

Myo6 – regulation of transcription

Foxa1 – regulation of transcription

 

Xbp1 – regulation of transcription

Aff3 – regulation of transcription

  

Npnt – cell adhesion

  

Anxa9 – cell – cell adhesion

  

Gpr160 – signal transduction

  

Slc39a6 – ion transport

  

Tff3 – defense response

  

Acadsb – lipid metabolic process

  

Nat1 – metabolic process

Luminal C (ER-positive, p53 mut): eight genes, six of which (75%) changed in stem-like stage

5 genes

1 genes

2 genes

Mybl2 – regulation of transcription

Ggh – glutamine metabolic process

Ywhaz – protein targeting

Ybx1 – transcription

 

Sqle – oxidation reduction

Tfrc – endocytosis

  

Ebna1bp2 – unknown function

  

Kif23 – cell cycle

  

Basal like (ER-negative, p53 mut): 15 genes, nine of which (60%) changed in stem-like stage

5 genes

4 genes

6 genes

Cdh3 – cell adhesion

Trim29 – transcription

Tnni2 – regulation of transcription

Lamc2 – cell adhesion

Slpi – serine – type endopeptidase inhibitor activity

Nfib – regulation of transcription

Krt17 – epidermis development

Galnt3 – metabolic process

Capn6 – proteolysis

Krt5 – epidermis development

Sox9 – transcription/regulation of cell proliferation

Dmd – peptide biosynthetic process

Cxcl1 – negative regulation of cell proliferation

 

Tgfb2 – apoptosis

  

Fabp7 – regulation of cell proliferation

  1. From Sorlie et al.[10]. Names and biological process (as defined by gene ontology, selected and/or abbreviated to fit table) are provided. ER, estrogen receptor.