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Table 3 Biological functions over-represented and under-represented in HC11 mammary stem-like cells

From: Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression

 

No genes

EASE score

Over-represented in stem-like cells

  

   Cell cycle

90

3.6 × 10-27

   DNA metabolism

72

1.7 × 10-23

   RNA metabolism

45

3.2 × 10-12

   Regulation of cell cycle

36

1.8 × 10-7

   Chromatin assembly/disassembly

14

2.0 × 10-5

   Protein amino acid phosphorylation

34

0.008

   Protein metabolism

118

0.01

Under-represented in stem-like cells

  

   Coenzyme metabolism

15

0.0003

   Cell adhesion

38

0.0007

   Vesicle-mediated transport

20

0.003

   Lipid metabolism

31

0.004

   Epithelial cell differentiation

4

0.005

   Regulation of apoptosis

15

0.005

   Cell differentiation

19

0.03

   Skeletal development

10

0.05

   Regulation of transcription, DNA dependent

72

0.13

  1. Biological function as defined by gene ontology. The stem-like cell gene expression is compared with expression in the pre-differentiated stage. Expression Analysis Systematic Explorer (EASE) score: modified Fischer exact probability t test.