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Table 3 Biological functions over-represented and under-represented in HC11 mammary stem-like cells

From: Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression

  No genes EASE score
Over-represented in stem-like cells   
   Cell cycle 90 3.6 × 10-27
   DNA metabolism 72 1.7 × 10-23
   RNA metabolism 45 3.2 × 10-12
   Regulation of cell cycle 36 1.8 × 10-7
   Chromatin assembly/disassembly 14 2.0 × 10-5
   Protein amino acid phosphorylation 34 0.008
   Protein metabolism 118 0.01
Under-represented in stem-like cells   
   Coenzyme metabolism 15 0.0003
   Cell adhesion 38 0.0007
   Vesicle-mediated transport 20 0.003
   Lipid metabolism 31 0.004
   Epithelial cell differentiation 4 0.005
   Regulation of apoptosis 15 0.005
   Cell differentiation 19 0.03
   Skeletal development 10 0.05
   Regulation of transcription, DNA dependent 72 0.13
  1. Biological function as defined by gene ontology. The stem-like cell gene expression is compared with expression in the pre-differentiated stage. Expression Analysis Systematic Explorer (EASE) score: modified Fischer exact probability t test.