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Table 1 Effective doses at 10, 50 and 90% effect levels of QLT0267 in human breast tumour cell lines

From: QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model

Cell line Drug concentration range (μM) ED10 (μM) ED50 (μM) ED90 (μM)
MDA MB 435/LCC6 2.0 to 256.0 2.05 17.2 143.6
MDA MB 435/LCC6her2/neu 2.0 to 256.0 1.66 12.2 90.4
MDA MB 468 1.0 to 133.3 0.91 25.6 718.7
MCF-7 1.0 to 133.3 1.15 9.8 83.3
KPL-4 2.0 to 256.0 0.31 12.1 473.0
BT-474 2.0 to 256.0 29.8 70.9 168.2
SKBR-3 2.0 to 256.0 28.8 55.8 108.2
  1. Effective doses (ED) values were calculated with Calcusyn software using the median effect principle defined by Chou and Talalay [26].