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Table 7 Univariate analysis of ER-positive cases with adjuvant hormonal

From: Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer

Variable NE (%) Classes N (%) Hazard Ratio [IC95] p-value ×
Age 0 (0%) < 45 years 29 (8%) 1 0.964
   >= 45 years 355 (92%) 1.02 [0.401–2.605]  
   < 45 29 (8%) 1 0.315
   45–60 155 (40%) 0.834 [0.312–2.226]  
   > 60 200 (52%) 1.32 [0.493–3.522]  
Tumoral size 2 (1%) < 25 mm 141 (37%) 1 0.0222
   >= 25 mm 241 (63%) 2.16 [1.1–4.23]  
Scarff-Bloom-Richardson grade 2 (1%) I 141 (37%) 1 0.000487
   II–III 241 (63%) 4.1 [1.74–9.644]  
VPI 3 (1%) absent 237 (62%) 1 0.00363
   present 144 (38%) 2.36 [1.305–4.268]  
N 3 (1%) N- 174 (46%) 1 0.0495
   N+ 207 (54%) 2.22 [1–4.921]  
   N < 3 288 (76%) 1 < 0.0001
   N >= 3 93 (24%) 3.81 [2.113–6.883]  
AR 66 (17%) 0 74 (23%) 1 0.306
   > 0 244 (77%) 0.712 [0.371–1.369]  
BCL2 66 (17%) 0 38 (12%) 1 0.0676
   > 0 280 (88%) 0.492 [0.226–1.069]  
CCND1 47 (12%) 0 97 (29%) 1 0.971
   > 0 240 (71%) 1.01 [0.542–1.886]  
ERBB2 36 (9%) 1 or 2 319 (92%) 1 0.558
   2 or 3 29 (8%) 1.32 [0.519–3.359]  
FOXA1 78 (20%) 0 3 (1%) 1 0.406
   > 0 303 (99%) 9220000 [0-Inf]  
GATA3 66 (17%) 0 70 (22%) 1 0.0952
   > 0 248 (78%) 0.599 [0.326–1.1]  
Ki67 60 (16%) < 20 299 (92%) 1 0.000304
   >= 20 25 (8%) 3.58 [1.709–7.488]  
P53 55 (14%) 0 272 (83%) 1 < 0001
   > 0 57 (17%) 3.13 [1.745–5.601]  
ER 0 (0%) < 120 153 (40%) 1 0.227
   >= 120 231 (60%) 0.71 [0.406–1.24]  
PR 44 (11%) 0 76 (22%) 1 0.941
   > 0 264 (78%) 0.975 [0.499–1.904]  
  1. NE: non evaluable cases on Tissu-micro arrays. × Logrank test stratified on chemotherapy.