Skip to main content

Advertisement

Table 4 Univariate analysis of 832 consecutive cases of breast carcinomas and 16 factors including classical histopronostic and immunohistochemical parameters

From: Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer

Variable NE (%) Classes N (%) Hazard Ratio [IC95] p-value
Hormonal therapy 0 (0%) no 361 (43%) 1 0.000209
   yes 471 (57%) 0.558 [0.408–0.763]  
Age 1 (0%) < 45 years 104 (13%) 1 0.673
   >= 45 years 727 (87%) 1.1 [0.711–1.696]  
   < 45 104 (13%) 1 0.145
Tumor Size 7 (1%) < 25 mm 381 (46%) 1 < 0.0001
   >= 25 mm 444 (54%) 2.47 [1.719–3.562]  
Scarff-Bloom-Richardson grade 22 (3%) I 266 (33%) 1 < 0.0001
   II–III 544 (67%) 3.69 [2.244–6.083]  
VPI 4 (0%) Absent 536 (65%) 1 < 0.0001
   present 292 (35%) 2.1 [1.519–2.897]  
Lymph node invasion 16 (2%) N- 442 (54%) 1 < 0.0001
   N+ 374 (46%) 2.61 [1.693–4.013]  
AR 175 (21%) 0 220 (33%) 1 0.0122
   > 0 437 (67%) 0.65 [0.463–0.913]  
   < 80 410 (62%) 1 0.00422
   >= 80 247 (38%) 0.568 [0.383–0.841]  
BCL2 201 (24%) 0 162 (26%) 1 0.000944
   > 0 469 (74%) 0.548 [0.381–0.787]  
CCND1 142 (17%) 0 284 (41%) 1 0.562
   > 0 406 (59%) 0.905 [0.647–1.268]  
ERBB2 123 (15%) 0 or 1 621 (88%) 1 0.209
   2 or 3 88 (12%) 1.33 [0.852–2.071]  
FOXA1 187 (22%) 0 40 (6%) 1 0.324
   > 0 605 (94%) 1.43 [0.698–2.952]  
GATA3 188 (23%) 0 247 (38%) 1 0.00024
   > 0 397 (62%) 0.534 [0.38–0.75]  
Ki67 171 (21%) < 20 560 (85%) 1 0.000748
   >= 20 101 (15%) 1.96 [1.316–2.923]  
P53 140 (17%) 0 525 (76%) 1 0.00095
   > 0 167 (24%) 1.76 [1.253–2.47]  
ER 79 (9%) 0 169 (22%) 1 0.000276
   > 0 584 (78%) 0.54 [0.386–0.756]  
PR 120 (14%) 0 263 (37%) 1 0.0875
   > 0 449 (63%) 0.752 [0.542–1.044]  
  1. NE: Number of non evaluable or miss cases on tissu microarrays.